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  1. Guaiacol
    GuaiacolChemical compound
    OverviewChemical structureFunctionpH
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    Guaiacol - Wikipedia

    Guaiacol (/ ˈ ɡ w aɪ ə k ɒ l /) is an organic compound with the formula C 6 H 4 (OH)(OCH 3). It is a phenolic compound containing a methoxy functional group. Guaiacol appears as a viscous …

    CAS Number90-05-1
    3D model (JSmol)Interactive image
    Occurrence

    Guaiacol is usually derived from guaiacum or wood creosote.
    It is produced by a variety of plants. It is also found in essential oils from celery seeds, tobacco leaves, orange leaves, and lemon peels. … See more

    Preparation

    The compound was first isolated by Otto Unverdorben in 1826. Guaiacol is produced by methylation of o-catechol, for example using potash and dimethyl sulfate:
    C6H4(OH)2 + (CH3O)2SO2 → C6H4(OH)(… See more

    Uses and chemical reactions

    Lignin, comprising a major fraction of biomass, is sometimes classified according to the guaiacyl component. Pyrolysis of lignin from gymnosperms gives more guaiacol, resulting from removal of the propenylSee more

    Safety

    Methoxyphenols are potential biomarkers of biomass smoke exposure, such as from inhalation of woodsmoke. Dietary sources of methoxyphenols overwhelm the contribution from inhalational exposures to woodsmoke. … See more

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  2. Guaiac Wood - The Perfume Society

    Apr 14, 2025 · There’s nothing light and airy about guaiac wood, that’s for sure. From the striped heartwood of a small tree called Palo Santo (Bulnesia sarmienti) – which translates as ‘tree of …

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    • What Does Guaiacwood Smell Like In Perfume? – Phlur

      Apr 17, 2023 · Obtained from the wood of the guaiacum officinalis tropical tree, native to South America and the Caribbean, guaiacwood is known for its distinct smoky, woody, and slightly …

    • Guaiacol: Preparation, applications and toxicity

      Jul 7, 2023 · Guaiacol is a naturally-occurring organic compound. Guaiacol is present in wood smoke, resulting from the pyrolysis of lignin. The chemical compound contributes to the flavor of many substances such as whisky and …

    • Guaiac Wood: What To Know About The Trendy …

      May 25, 2023 · Guaiac wood is appearing in several of the latest perfumes to hit the market. Here are a few things to know about the woody, smokey fragrance note.

    • GUAIAC WOOD - Uses, Side Effects, and More - WebMD

      Guaiac (Guaiacum officinale) is a tree. The wood and sap (resin) of the tree are used to prepare medicinal extracts. As a flavoring agent, guaiac wood is used in foods and in edible oils and...

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    • What the Hell Is That Smell? It's Guaiacwood - P. F.

      Feb 21, 2023 · Guaiacwood yields an oil with a warm scent and perfumers commonly use it to bind and harmonize different woody notes together. Scent notes depend on its form, but as an oil, it has a balsamic and slightly smoky …

    • Guaiac Wood perfume ingredient, Guaiac Wood fragrance and …

      Guaiac Wood is one of the hardest and most resilient woods in the world. Its heartwood is brown, black or green, with elegant streaks. It also provides high-quality charcoal and good timber.

    • Essential Oil Spotlight: Guaiacwood - AromaTools®

      Guaiacwood (Bulnesia sarmientoi)—pronounced GWHY-ack-wood—is steam distilled from the heartwood of the plant. It belongs to the Zygophyllaceae botanical family and is native to parts of South America. The aroma is woodsy …

    • What Is Guaiacol? | Aromatic Compound Insights

      Guaiacol is a colorless to yellowish liquid with a sweet, smoky aroma reminiscent of burnt wood. It belongs to a class of compounds known as phenols and is structurally classified as a …

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