Glutamine synthetase (GS) (EC 6.3.1.2) [3] is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH 3 → Glutamine + ADP + phosphate.

Glutamine synthetase (GS) is an enzyme that is responsible for catalyzing the reaction that synthesizes glutamine from glutamate and ammonia. Additionally, GS catalyzes the reverse reaction of …

Glutamine synthetase (GS) is the adenosine triphosphate (ATP)-dependent enzyme that catalyses the synthesis of glutamine by condensing ammonium to glutamate. In the circulatory system, glutamine carries ammonia from muscle and brain to the kidney and liver.

Aug 3, 2018 · Glutamine synthetase (GS) is an enzyme that regulates nitrogen metabolism and synthesizes glutamine via glutamate, ATP, and ammonia. GS is a homo-oligomeric protein of eight, ten, or twelve...

Glutamine synthetase is a cytosolic enzyme that catalyzes the synthesis of glutamine from glutamate and free NH 4 + in an ATP-dependent reaction (Fig. 1). The human gene encoding glutamine synthetase has been mapped to chromosome 1q25.

Glutamine synthetase (E.C. 6.3.1.2) - an enzyme catalyzing formation of glutamine from glutamate and ammonium ion, is one of the most important enzymes in nitrogen metabolism. Due to glutamine synthetase activity, inorganic nitrogen is incorporated in the cell metabolism and is further used in biosy …

Glutamine synthetase (GS) is an ATP-dependent enzyme found in most species that synthesizes glutamine from glutamate and ammonia. In brain, GS is exclusively located in astrocytes where it serves to maintain the glutamate-glutamine cycle, as well as nitrogen metabolism.

Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the ...

Jan 22, 2025 · Glutamine synthetase (GS) is the ATP (ATP)-dependent enzyme that catalyzes the synthesis of glutamine by condensing ammonium to glutamate. In the circulatory system, glutamine carries ammonia from muscle and brain to the kidney and liver.

Glutamine supplies substrates for nucleotide, nonessential amino acid, nicotinamide adenine dinucleotide phosphate (NADPH), and glutathione (GSH) synthesis. Thus, glutamine provides the building block for macromolecules, regulates pH homeostasis, and controls redox balance.