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Apr 1, 2018 · Rescue experiments showed that GLO-4 expressed in GABAergic motor neurons functioned as a suppressor of miR-51. Disruption of glo-1 or AP-3 gene apm-3 attenuated the defects of GABAergic synapse in mir-51 mutants, suggesting miR-51 regulated GABAergic synapses through GLO/AP-3 pathway.

Apr 1, 2018 · miR-51 regulates GABAergic synapses by inhibiting GLO-4 in GABAergic motor neurons. GLO/AP-3 pathway is required for miR-51 modulating GABAergic synapses. A deficit of GABA (γ-aminobutyric acid) transmission will lead to epilepsy and other cognitive disorders.

We define a class of gut granule loss (glo) mutants that are defective in gut granule biogenesis. We show that the glo-1 gene encodes a predicted Rab GTPase that localizes to lysosome-related gut granules in the intestine and that glo-4 encodes a possible GLO-1 guanine nucleotide exchange factor.

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Here, we report the identification of an RCC1-like guanine nucleotide exchange fac-tor, GLO-4, from mass spectrometry analysis of RPM-1-associated proteins. GLO-4 colocal-izes with RPM-1 at presynaptic terminals. Loss of function in glo-4 or in its target Rab GTPase, glo-1, causes neuronal defects resembling those in rpm-1 mutants.

Aug 16, 2007 · Loss of function in glo-4 or in its target Rab GTPase, glo-1, causes neuronal defects resembling those in rpm-1 mutants. We show that the glo pathway functions downstream of rpm-1 and acts in parallel to fsn-1, a partner of RPM-1 E3 ligase function.

Inner primer WT PCR product: 2769. glo-4 (ok623) causes a a partially-penetrant Dpy phenotype.

[Wormbase] glo-4 encodes a guanine nucleotide exchange factor (GEF) that is similar to Drosophila Claret and human RP3; throughout development, glo-4 activity is required for biogenesis of the lysosome-related gut granules; based upon phenotypic similarity, glo-4 is likely to encode a GEF for the GLO-1 Rab-like GTPase; in regulating gut granule ...