Growth arrest – specific 6, also known as GAS6, is a human gene coding for the GAS6 protein. It is similar to the Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

Mar 30, 2025 · GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Diseases associated with GAS6 include Mesangial Proliferative Glomerulonephritis and Lupus Erythematosus. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

It is accepted that the Gas6/TAM pathway can promote the malignant transformation of various types of cancer cells. Gas6 has the highest affinity for Axl, an important member of the TAM receptor family. Knockdown of the TAM receptors Axl …

GAS6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. GAS6 has a high structural homology with the natural anticoagulant protein S, sharing the same modular composition and having 40% sequence identity.

Our data propose GAS6 as an independent predictor of poor survival, suggesting GAS6, both on the mRNA and on the protein level, as a potential biomarker for ovarian cancer. Gas6 was uniquely upregulated in either endothelial/mesangial cells or podocytes in IgA nephropathy.

Jul 1, 2017 · GAS6 regulates thrombin signaling on endothelial cells supporting CCL2-mediated recruitment of proinflammatory CCR2 hi CX3CR1 lo monocytes by increasing PSGL-1 expression, thus augmenting thrombus growth in the IVC thrombosis.

Mar 23, 2017 · Gas6 has a critical role in the development of multiple types of cancers, including pancreatic, prostate, oral, ovarian and renal cancers. Acute myelocytic leukaemia (AML) is a Gas6-dependent...

Gas6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. Gas6 has a high structural homology with the natural anticoagulant protein S, sharing the same modular composition.

Dec 9, 2024 · Circulating growth arrest-specific 6 protein is associated with adiposity, systemic inflammation, and insulin resistance among overweight and obese adolescents. Hsiao FC, et al. J Clin Endocrinol Metab, 2013 Feb. PMID 23341490. Serum levels of growth arrest specific protein 6 are increased in preeclampsia. Stepan H, et al. Regul Pept, 2013 Mar 10.

Growth arrest-specific gene 6 (Gas6), identified in 1995, acts as the ligand to the Axl/Tyro3 family of tyrosine kinase receptors and exerts mitogenic activity when bound to these receptors. Overexpression of the Axl/Tyro3 receptor family has been found in …