Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene. [5][6][7] This gene is a member of a group of genes, the GADD45 genes, whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents (mutagens).

Mar 30, 2025 · GADD45A (Growth Arrest And DNA Damage Inducible Alpha) is a Protein Coding gene. Diseases associated with GADD45A include Pancreatic Adenocarcinoma and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Endometrial cancer and Gene expression (Transcription).

Apr 7, 2025 · Title: Loss of the stress sensor GADD45A promotes stem cell activity and ferroptosis resistance in LGR4/HOXA9-dependent AML. Activation of the MEK/ERK Pathway Mediates the Inhibitory Effects of Silvestrol on Nasopharyngeal Carcinoma Cells via RAP1A, HK2, and GADD45A.

Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress. Cancer Res. 2010;70:9671–9681. doi: 10.1158/0008-5472.CAN-10-2177. [ DOI ] [ PMC free article ] [ PubMed ] [ Google Scholar ]

The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis.

The Growth Arrest and DNA Damage or gadd45 genes, including GADD45A (originally termed gadd45) GADD45B (originally termed MyD118), and GADD45G (originally termed CR6), are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation.

Growth arrest and DNA damage-inducible 45 alpha (GADD45a) is a repressive gene implicated in cell cycle regulation, as well as in human cancers development. However, its role in BC remains to be determined.

Jul 4, 2024 · In this issue of Blood, Hassan et al 1 have identified GADD45A as a pivotal tumor suppressor that acts as a key downstream target of leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4), which governs the self-renewal capacity and therapy resistance of LGR4/HOXA9 -dependent acute myeloid leukemia (AML) stem cells (LSCs).

Growth arrest and DNA‐damage‐inducible 45 alpha (GADD45A) is induced by genotoxic stress in HSCs. GADD45A has been implicated in cell cycle control, cell death and senescence, as well as in DNA‐damage repair.

Jan 6, 2005 · Gadd45a, a p53- and BRCA1-regulated stress-inducible gene, has been characterized as one of the important players that participate in cellular response to a variety of DNA damage agents.