Piperlongumine inhibits hepatocellular carcinoma growth by …
Jul 1, 2024 · High throughput screening identified GSTP1 as a critical gene for PIP action. Functional validation of HCC cells by constructing cell lines with knockout or overexpression of …
SMURF2 predisposes cancer cell toward ferroptosis in GPX4
Nov 27, 2023 · Glutathione (GSH) peroxidase 4 (GPX4) and GSH-independent ferroptosis suppressor protein 1 (FSP1) have been identified as major defenses. Here, we uncover a …
The Journal of Pharmacology and Experimental Therapeutics
We have created a novel glutathione S-transferase π1 (gstp1) knockout (KO) zebrafish model and used it for comparative analyses of redox homeostasis and response to drugs that cause …
Glutathione S-Transferase P Influences Redox Homeostasis and ... - PubMed
We have created a novel glutathione S-transferase π1 (gstp1) knockout (KO) zebrafish model and used it for comparative analyses of redox homeostasis and response to drugs that cause …
Kindlin-2 maintains liver homeostasis by regulating GSTP1–OPN …
Kindlin-2 regulates GSTP1 expression by affecting its polyubiquitination. A, immunoblotting analysis of GSTP1 protein levels in primary hepatocyte isolated from Kindlin-2 KO and control …
Glutathione transferases P1/P2 regulate the timing of ... - Nature
Jan 15, 2015 · Our data demonstrate that GSTP1/P2 contribute to the finely tuned activation levels of proliferation signaling pathways and to the downstream expression of cell cycle …
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that ...
May 1, 2023 · In our research, GSTP1 was revealed to upregulate the S-glutathionylation level of Pik3r1 through Cys498 and Cys670, thereby decreasing its phosphorylation, further controlling …
FBX8 degrades GSTP1 through ubiquitination to suppress
Apr 25, 2019 · FBX8 directly targets GSTP1 for ubiquitin-mediated proteasome degradation in CRC. GSTP1 promotes the proliferation, invasion, and metastasis of CRC cells. Furthermore, …
Gstp1-KO - 南模生物
敲除Gstp1基因exon 3-5，建立Gstp1基因敲除小鼠模型。 *使用本品系发表的文献需注明: Gstp1-KO mice (Cat. NO. 待定) were purchased from Shanghai Model Organisms Center, Inc.. 相关 …
Glutathione - Journal of Pharmacology and Experimental …
We have created a novel glutathione S-transferase π1 (gstp1) knockout (KO) zebrafish model and used it for comparative analyses of redox homeostasis and response to drugs that cause …