Glucose transporter 2 (GLUT2) also known as solute carrier family 2 (facilitated glucose transporter), member 2 (SLC2A2) is a transmembrane carrier protein that enables protein facilitated glucose movement across cell membranes.

Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and ...

In the nervous system, GLUT2-dependent glucose sensing controls feeding, thermoregulation and pancreatic islet cell mass and function, as well as sympathetic and parasympathetic activities.

Glucose transporter 2 (GLUT2) is encoded by the SLC2A2 gene that is located on human chromosome 3 and contains 11 exons. Its product is a peptide with 12 membrane-spanning domains containing several sites for glucose binding.

May 1, 2009 · Cloned 20 years ago, GLUT2 is a facilitative glucose transporter in the liver, pancreas, intestine, kidney, and brain. It ensures large bidirectional fluxes of glucose in and out the cell due to it...

GLUT2 partakes in glucose uptake (Km = 17 mM), but its main substrate is glucosamine (Km = 0.8 mM) [6]. It also transports fructose, galactose, and mannose (Km = 76 mM, 92 mM and 125 mM, respectively) [20, 21, 22].

Nov 25, 2014 · In rodent pancreatic beta cells, GLUT2 is the major glucose transporter and its genetic inactivation suppresses glucose uptake and glucose-stimulated insulin secretion (GSIS). GLUT2 is also expressed in the central nervous system.

Human GLUT2 and GLUT3, members of the GLUT/SLC2 gene family, facilitate glucose transport in specific tissues. Their malfunction or misregulation is associated with serious diseases, including diabetes, metabolic syndrome, and cancer. Despite being ...

Oct 26, 2023 · Here we show that the low-affinity, concentration-dependent glucose transporter 2 (Glut2) regulates the development of CD8+ T cell effector responses in mice by promoting glucose uptake ...

Jun 26, 2023 · Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and ...