Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene. [5] [6] FAT4 is associated with the Hippo signaling pathway. [7]

Mar 30, 2025 · FAT4 (FAT Atypical Cadherin 4) is a Protein Coding gene. Diseases associated with FAT4 include Van Maldergem Syndrome 2 and Hennekam Lymphangiectasia-Lymphedema Syndrome 2 . Among its related pathways are Kidney development and Markers of …

The FAT4 gene provides instructions for making a protein that is found in most tissues. The protein spans the membrane surrounding cells so that part of the protein is outside the cell and part of the protein is inside the cell.

Sep 1, 2023 · Here, we report the mechanism by which FAT4 overexpression regulates anti-tumor immunity in cervical cancer by inhibiting PD-L1 N-glycosylation and cell membrane localization in a β-catenin-dependent manner. Methods: FAT4 expression was first detected in cervical cancer tissues and cell lines.

We performed a pan-cancer analysis to explore the potential mechanisms of FAT4 in 33 different tumors. In this study, we selected 33 types of cancers based on the datasets of TCGA (the cancer genome atlas). We analyzed the expression of FAT4 in tumor and normal tissues.

Feb 8, 2025 · Increased expression of FAT4 suppress metastasis of lung adenocarcinoma through regulating MAPK pathway and associated with immune cells infiltration. A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors. FAT4 identified as a potential modifier of orofacial cleft laterality.

FAT4 gene is recurrently mutated in several types of human cancers, such as melanoma, pancreatic cancer, gastric cancer and hepatocellular carcinoma. FAT1 and FAT4 suppress tumor growth via activation of Hippo signaling, whereas FAT1 promotes tumor migration via induction of actin polymerization.

Mar 3, 2019 · FAT4 is the mammalian ortholog of Drosophila fat (ft). Two well-defined Ft interacting proteins, Dachsous (Ds) and Four-jointed (Fj), have homologs in mammals (DCHS1, DCHS2, FJX1).

Nov 27, 2024 · Increased expression of FAT4 suppress metastasis of lung adenocarcinoma through regulating MAPK pathway and associated with immune cells infiltration.

The FAT4 gene encodes a protein that is a member of a large family of protocadherins. DCHS1 ( 603057 ) is another protocadherin that is the ligand for FAT4; FAT4 and DCHS1 form an apically located adhesive complex in the developing brain (summary by Cappello et al., 2013 ).