Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. [5] .

Mar 30, 2025 · FOXO1 (Forkhead Box O1) is a Protein Coding gene. Diseases associated with FOXO1 include Rhabdomyosarcoma 2 and Diffuse Large B-Cell Lymphoma. Among its related pathways are IL-9 Signaling Pathways and FOXO-mediated transcription.

In summary, this study demonstrates the versatile nature of FOXO1A in the regulation of a number of decidualization-specific genes. The forkhead box O1A (FOXO1A) has been identified as one gene that is up-regulated early in the decidualization process.

Nov 8, 2021 · FKH1; FKHR; FOXO1A. This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation.

Mounting evidence suggests that the human FOXO1 protein, a founding member of the FoxO family is likely involved in carcinogenesis, diabetes and other human diseases.

FoxO1 is a unifying regulator of energy metabolism through the skeleton and peripheral organs. FoxO1 promotes glucose production by suppressing β-cell proliferation and insulin synthesis, by suppressing insulin sensitivity in the liver and white adipose tissue and by inducing expression of gluconeogenic enzymes.

Feb 27, 2008 · As a first step towards identifying transcriptional pathways that have been remodeled in the human lineage, we focused on a transcription factor, FOXO1a, which we had previously found to be up-regulated in the human liver compared to …

Jul 1, 2010 · In this study we tested the hypothesis that targeting of the FKHR transcription factor FOXO1A in HER2 overexpressing breast tumor cells, can overcome the Trastuzumab resistance in vitro.

Oct 27, 2023 · FOXO isoforms exert a differential role in human aging and in several age-related diseases. Pharmacological inhibition or activation of FOXO proteins for therapeutic or preventive purposes has...

Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. None. The gene represented in this entry may …