Eotaxin is a special CC chemokine because it primarily attracts eosinophils. [2] By being a chemoattractant for eosinophils, eotaxin has a direct relationship with inflammation. This is because eosinophils are known to promote inflammation. In order to induce stimulation, eotaxin binds with the CCR-3 receptor.

Eotaxins are a potent stimulators of specific cell types. Eotaxin-1 is considered as a chemoattractant mainly for eosinophils, but also basophils, T helper 2 lymphocytes, thymocytes, macrophages, and mast cells.

C-C motif chemokine 11 also known as eosinophil chemotactic protein and eotaxin-1 is a protein that in humans is encoded by the CCL11 gene. This gene is encoded on three exons and is located on chromosome 17 .

Eotaxin is a small protein produced in the lungs of asthmatic patients that attracts eosinophils, a type of white blood cell, by interacting with a specific receptor on their surface. It plays a role in the recruitment of eosinophils to lung tissue, which is associated with the pathogenesis of asthma.

Jul 1, 1999 · Eotaxin was distinguished from all other chemokines because it was found to be a potent eosinophil-selective chemoattractant having minimal activity on other leukocytes. Eotaxin was also identified as a potent activator of eosinophils capable of inducing superoxide generation and the release of granule proteins.

A potent eosinophil chemoattractant is produced in the asthmatic lung. This small protein, the chemokine eotaxin, is synthesized by a number of different cell types, and is stimulated by interleukin-4 and interleukin-13, which are produced by T-helper (Th)2 lymphocytes.

Here, we briefly review known functions of eotaxin family members during innate immunity, and then focus on whether and how these molecules might participate in the progression of neurodegenerative diseases.

Jan 1, 2000 · Defining the mechanisms that control recruitment of eosinophils to tissues is fundamental to understanding these disease processes and provides targets for novel drug therapy. An important discovery in this context was the identification of an eosinophil-specific chemoattractant, eotaxin.

Eotaxin is an eosinophil-selective chemokine that is constitutively expressed in a variety of organs such as the intestine. Previous studies have demonstrated that the recruitment of eosinophils during inflammation is partially dependent on eotaxin, ...

Nov 1, 1999 · Here, Jose Carlos Gutierrez-Ramos and colleagues review the chemotactic effects of eotaxin on eosinophils and T helper type 2 cells, its differentiation and migration effects on mast cells and its actions on progenitors and mature cells in the bone marrow.