The enzyme phospholipase A 2 (EC 3.1.1.4, PLA 2, systematic name phosphatidylcholine 2-acylhydrolase) catalyses the cleavage of fatty acids in position 2 of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule: phosphatidylcholine + H 2 O = 1-acylglycerophosphocholine + a carboxylate

May 1, 2023 · Phospholipase A (PLA) comprises a supergroup of esterase enzymes present in all human cells that play a key role in mediating the production of free fatty acids and lysophospholipids from glycerophospholipids.

Two possibilities are shown: top, the “surface binding model” whereby the enzyme first associates nonspecifically with the micelle surface; and bottom, the “phospholipid binding model” whereby the enzyme first associates specifically with phospholipid in the micelle surface.

Phospholipase A2 (PLA2) belongs to the lipolytic family of enzymes that hydrolyze the ester bond at the sn-2 position of the phospholipids. Upon hydrolysis of the phospholipids, PLA2s release free fatty acids and generate lysophospholipids (LPLs).

The phospholipase A2 (PLA2) family of proteins includes lipolytic enzymes that liberate the sn-2 fatty acyl chains from phospholipids to yield non-esterified fatty acids and lysophospholipids. The purpose of this review is to discuss recent findings ...

Oct 7, 2008 · Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cells

Tremendous advances in understanding the structure and function of the superfamily of phospholipase A2 (PLA2) enzymes has occurred in the twenty-first century. The superfamily includes 15 groups comprising four main types including the secreted sPLA2, cytosolic cPLA2, calcium-independent iPLA2, and …

Phospholipase A 2 (PLA 2) designates a class of enzymes that hydrolyze the sn-2 ester of glycerophospholipids to produce a fatty acid and a lysophospholipid.

Oct 12, 2011 · Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention Chem Rev . 2011 Oct 12;111(10):6130-85. doi: 10.1021/cr200085w.

Phospholipase A2 breaks membrane lipids, forming molecules that contribute to inflammation and pain signaling. Pancreatic phospholipase A2, with calcium in green and cysteine sulfur atoms in yellow. Over 100 years ago, scientists discovered that an enzyme in snake venom breaks the lipid molecules in cellular membranes.