Nidogen-1 (NID-1), formerly known as entactin, is a protein that in humans is encoded by the NID1 gene. [5] [6] Both nidogen-1 and nidogen-2 are essential components of the basement membrane alongside other components such as type IV collagen, proteoglycans (heparan sulfate and glycosaminoglycans), laminin [7] and fibronectin. [8]

Nidogen，也称为Entactin，是基底膜（basement membranes）的主要结构成分。 1983年，Timpl描述了一个新的更小的蛋白质，这是基底膜的一个普遍的组成成分。 由于它具有聚合成类似于巢结构的能力，建议将其命名为“nidogen” (源自拉丁语nidus = nest和generare = to produce) （注：笔者认为，如果将nidogen翻译为筑巢蛋白/构巢蛋白是否贴切一点）。 基底膜无处不 …

Nidogens, formerly known as entactins, are a family of sulfated monomeric glycoproteins located in the basal lamina [1] of parahoxozoans. [2] . Two nidogens have been identified in humans: nidogen-1 (NID1) and nidogen-2 (NID2). [3] .

Mar 14, 2024 · Nidogen, also known as entactin, is a multifunctional glycoprotein that plays a crucial role in the maintenance of the basement membrane (BM), morphogenesis and neuronal plasticity. This review aims to provide an overview of the structural features, molecular interactions and diverse functions associated with Nidogen.

Mar 30, 2025 · Diseases associated with NID1 include Isolated Dandy-Walker Malformation Without Hydrocephalus and Focal Epilepsy. Among its related pathways are Extracellular matrix organization and Non-integrin membrane-ECM interactions. Gene Ontology (GO) annotations related to this gene include calcium ion binding and laminin binding.

Oct 20, 2018 · Gene name - Nidogen/entactin. Synonyms - Cytological map position - 47A1-47A1 Function - secreted basement membrane component. Keywords - basement membrane component, required for proper assembly and maintenance of certain basement membranes of the adipose tissue and flight muscles, binds to and couples Collagen IV and Laminin networks

A glycoprotein that binds to laminin and type IV collagen in the basal lamina of the renal glomerulus and is a major cell attachment factor; entactin is a sulfated calcium-binding protein. Synonym(s): nidogen

High concentration laminin/entactin complex frozen in Dulbecco's PBS One or more facilities manufacturing this product is 100% covered by renewable energy through the purchase of unbundled energy attribute certificates (EACs).

Nidogen-1 (also entactin) is a 150 kDa, secreted, monomeric glycoprotein that serves as a major linking component of basement membranes (1 - 4). It is synthesized as a 1247 amino acid (aa) precursor with a 28 aa signal sequence and a 1219 aa mature protein.

Entactin is a sulfated glycoprotein that is found in the extracellular matrix and is synthesized by mouse endodermal cells in culture. Its primary function is to facilitate basement membrane assembly by binding to collagen type IV, laminin, proteoglycans, and fibronectin.