Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene. [5][6][7] This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp - Glu - Ala -Asp (DEAD), are putative RNA helicases.

Mar 28, 2025 · EIF4A3 (Eukaryotic Translation Initiation Factor 4A3) is a Protein Coding gene. Diseases associated with EIF4A3 include Robin Sequence With Cleft Mandible And Limb Anomalies and Cortical Dysplasia, Complex, With Other Brain Malformations 13 .

In this review, we explored the predicted structures of the three eIF4A isoforms (eIF4A1, eIF4A2, and eIF4A3), and discussed possible explanations for which function during different translation stages (initiation, mRNA localization, export, and mRNA splicing).

EIF4A3, a member of the DEAD-box protein family, is a nuclear matrix protein and a core component of the exon junction complex (EJC). Under physiological conditions, EIF4A3 participates in post-transcriptional gene regulation by promoting EJC ...

EIF4A3 (eukaryotic translation initiation factor 4A3) is an RNA helicase and core component of the exon junction complex. While this RNA-binding protein (RBP) is well-characterized for its crucial roles in splicing, RNA trafficking and ...

EIF4A3 serves as a prognostic and immunosuppressive microenvironment factor and inhibits cell apoptosis in bladder cancer. EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling.

Jun 22, 2021 · Among the top regulators, we identified the eukaryotic translation initiation factor 4A-3 (eIF4A3). Here we show that depletion of eIF4A3 leads to a potent increase in autophagosome and...

Aug 11, 2021 · Here, we review the physiological role of EIF4A3 and the potential association between EIF4A3 overexpression and tumorigenesis. We also evaluate the protein's potential utility as a diagnosis biomarker, therapeutic target, and prognosis indicator, hoping to provide new ideas for future research.

Feb 9, 2025 · Title: EIF4A3 is stabilized by the long noncoding RNA BC200 to regulate gene expression during Epstein-Barr virus infection. Circular RNA hsa_circ_0000467 promotes colorectal cancer progression by promoting eIF4A3-mediated c-Myc translation.

Sep 30, 2023 · EIF4A3 represents a novel m6A suppressor that exerts control over the global m6A mRNA modification level, therefore influencing gene destiny.