EEF2 - Wikipedia
Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G. [5] [6] [7] [8] This gene encodes a …
EEF2 Gene - GeneCards | EF2 Protein | EF2 Antibody
Mar 30, 2025 · EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include Spinocerebellar Ataxia 26 and Diphtheria . Among its …
Eukaryotic elongation factor-2 (eEF2): its regulation and
The important component of eEFs, i.e. eEF2 promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. Mostly the eEF2 is …
Elongation factor 2 in cancer: a promising therapeutic target in ...
Dec 20, 2024 · Eukaryotic elongation factor 2 (eEF2) is an essential regulator of protein synthesis that precisely elongates nascent peptides in the protein elongation process.
Expansion of clinical and variant spectrum of EEF2-related ...
Eukaryotic translation elongation factor 2 (eEF2), encoded by the gene EEF2, is an essential factor involved in the elongation phase of protein translation. A specific heterozygous …
Deep mutational analysis of elongation factor eEF2 residues …
An emerging body of research is revealing mutations in elongation factor eEF2 that are implicated in both inherited and de novo neurodevelopmental disorders. Previous structural analysis has …
Functionally distinct roles for eEF2K in the control of ... - Nature
Nov 23, 2021 · Here, we uncover key roles for eEF2 kinase (eEF2K) in the control of ribosome availability and p-body abundance. eEF2K acts on a sole known substrate, eEF2, to inhibit …
FAM86A methylation of eEF2 links mRNA translation elongation to ...
May 2, 2024 · Here, we find that FAM86A methylation of eEF2 regulates nascent elongation to promote protein synthesis and lung adenocarcinoma (LUAD) pathogenesis. The principal …
Identification of elongation factor-2 as a novel regulator of ...
May 10, 2022 · Eukaryotic elongation factor-2 (eEF2), encoded by EEF2 gene that localizes on chromosome 19 in humans and a monomeric protein of 858 amino acid residues, is a key …
Accuracy mechanism of eukaryotic ribosome translocation
Dec 1, 2021 · Here we report a high-resolution X-ray structure of the eukaryotic 80S ribosome in a translocation-intermediate state containing mRNA, naturally modified eEF2 and tRNAs.