Integrin - Wikipedia
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. [3] Upon ligand binding, integrins activate signal transduction pathways that mediate …
ECM-binding properties of extracellular vesicles: advanced delivery ...
1 day ago · Integrins as one of most well-known adhesive transmembrane receptors expressed on the surface of EVs, contribute to EVs’ selective targeting. Integrins consist of an alpha (18 …
Organization, dynamics and mechanoregulation of integrin
Sep 27, 2022 · Integrins directly engage ECM ligands (such as RGD ligands) and connect to the cytoskeletal scaffold via various intermediary adaptor proteins, providing multiple points for …
Mechanisms of assembly and remodelling of the extracellular …
Sep 2, 2024 · Dynamic reciprocity initiated by ECM ligand–ECM receptor interactions (for example, fibronectin–integrins) contributes to ECM remodelling in several ways: ECM …
Novel tools to study cell-ECM interactions, cell adhesion dynamics …
Jun 1, 2024 · Application of a secondary Streptavidin-conjugated ECM ligand (SA-ECM) thus enables a rapid conversion of the non-adhesive area to support specific cell-matrix interactions …
Mixed Extracellular Matrix Ligands Synergistically Modulate …
These results demonstrate that mixed ECM ligand surfaces exhibit high specificity for the corresponding receptor and minimal cross-reactivity or transactivation between α 5 β 1 and α 2 …
Integrins as biomechanical sensors of the microenvironment
Jun 10, 2019 · Integrins, and integrin-mediated adhesions, have long been recognized to provide the main molecular link attaching cells to the extracellular matrix (ECM) and to serve as …
ECM receptors in neuronal structure, synaptic plasticity, and …
During central nervous system development, extracellular matrix (ECM) receptors and their ligands play key roles as guidance molecules, informing neurons where and when to send …
Integrin adhesion complexes: Current Biology - Cell Press
May 24, 2021 · At the external surface, integrin receptors are activated through binding to ECM ligands and this leads to recruitment of a large, heterogenous multiprotein signalling platform …
Recapitulating dynamic ECM ligand presentation at biomaterial ...
Jan 24, 2022 · Biomaterial surfaces with dynamic ligand presentation are capable of mimicking the dynamic biochemical cues of ECM, showing ECM-like functions to modulate cell …