Single-cell RNA sequencing of human double-negative T cells
5 days ago · PMID: 40246580 DOI: 10.1136/jitc-2024-010684 Abstract Background: Allogeneic double-negative T-cell (DNT) therapy has emerged as a novel, off-the-shelf cellular treatment …
DNT Cell-based Immunotherapy: Progress and Applications
Mar 31, 2020 · CD3+CD4-CD8- double negative T cells (DNTs) have emerged as functional antitumor effector cells, according to the definition of adoptive immunotherapy. They constitute …
Double-negative T cells in autoimmune diseases - PubMed
Mar 1, 2021 · Purpose of review: TCRαβ+CD4-CD8- double-negative T (DNT) cells, a principal subset of mature T lymphocytes, have been closely linked with autoimmune/inflammatory …
DNT Cell-based Immunotherapy: Progress and Applications
CD3+CD4-CD8- double negative T cells (DNTs) have emerged as functional antitumor effector cells, according to the definition of adoptive immunotherapy. They constitute a kind of T cell …
Double-negative T cells with a distinct transcriptomic profile are ...
Double-negative T (DNT) cells comprise a distinct subset of T lymphocytes that have been implicated in immune responses. The aim of this study was to characterize the peripheral DNT …
Targeting chemotherapy-resistant leukemia by combining DNT …
Apr 24, 2018 · We have recently shown that allogeneic double negative T cells (DNTs) are able to target the majority of primary AML blasts in vitro and in patient-derived xenograft models. …
Targeting late-stage non-small cell lung cancer with a …
Mar 11, 2019 · Our data show that DNT cells are cytotoxic to lung cancer cells in vitro and can inhibit the progression of late-stage lung cancer in vivo. DNT cell treatment in combination with …
Double-negative T cells utilize a TNFα-JAK1-ICAM-1 cytotoxic axis ...
Jun 25, 2024 · Allogeneic double-negative T cells (DNTs) are a rare T-cell subset that effectively target acute myeloid leukemia (AML) without inducing graft-versus-host disease in an …
Strategies to improve the regulatory assessment of developmental ...
Currently, the identification of chemicals that have the potential to induce developmental neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic testing …
Recommended DNT Reference Chemical Test Set For In Vitro …
Dec 17, 2024 · Recently OECD published an initial guidance document for use of the Developmental Neurotoxicity In Vitro Battery (DNT IVB), composed of in vitro assays that …