GTS-21 (DMXBA or DMBX-anabaseine) is a drug has been ability to potentially enhance memory and cognitive function. It has been studied for its potential therapeutic uses, particularly in the treatment of neurodegenerative diseases and psychiatric disorders.

Nov 18, 2007 · GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials.

A synthetic derivative, 3- (2,4-Dimethoxybenzylidene)-Anabaseine (DMXBA; also called GTS-21), improves memory in experimental animals and humans and is currently in clinical trials to determine whether it can ameliorate cognitive problems associated with schizophrenia.

DMXB-A improved performance on both the repeatable battery for assessment for neuropsychological status (RBANS) total scale score and the attention scale. DMXB-A also normalized the P50 ratio as well as the test wave amplitude, a more specific measure of inhibition.

Jan 7, 2025 · DMXB-A (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials.

GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials.

The agent 3- (2,4-dimethoxybenzylidene) anabaseine (DMXB-A) is a partial alpha (7)-nicotinic agonist and can be taken orally. A phase 1 trial showed evidence for cognitive enhancement in schizophrenia.

We found that the treatment with DMXB on days 1-10 after Abeta (25-35) injection dose-dependently prevented Abeta (25-35)-induced impairment of acquisition performance and probe trail test in Morris water maze.

GTS-21 dihydrochloride is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (K i. =20 nM for humanα4β2) and 5-HT3A receptor (IC50 =3.1 μM) antagonist [1] [2].

Mar 30, 2000 · The alpha7-selective agonists 3-(2, 4-dimethoxybenzylidene)-anabaseine (GTS-21), also known as DMXB, and 3-(4-hydroxy,2-methoxybenzylidene)anabaseine (4OH-GTS-21) produce a variety of behavioral and cytoprotective effects that may be related to the activation of either large transient currents at hi …