DART regimen, and 32 patients received a reduced version of the DART regimen (0.72 mg/kg over 7 days). They reported similar successful extubation rates (defined as extubation within 14 days of starting therapy and remaining extubated for more than 72 hours) in both groups: 56% in 7-day group and 67% in 10-day group. The average time

The most commonly studied protocol is the DART (Dexamethasone: A Randomized Trial) protocol, which involves a lower dose (total 0.89 mg/kg) over 10 days for the treatment of BPD in preterm infants . Despite its long-standing use, BPD remains a …

Late dexamethasone ( >/= 8 days ) should be reserved for treatment/prevention of BPD in mechanically ventilated patients at high risk (>65%) for BPD. (BPD Estimator) The DART study dosing regimen should be used for the treatment course …

Both hydrocortisone (utilizing the STOP-BPD regimen) and dexamethasone (utilizing the DART regimen) facilitate extubation without NDI. In our practice, if a steroid is to be given before day 21, we consider hydrocortisone, rather than dexamethasone, due to dexamethasone’s neurological harm observed in animal models and retrospective data ...

Sep 1, 2007 · One of the objectives of the DART (Dexamethasone: A Randomized Trial) study was to determine the long-term effects of low-dose dexamethasone. Unfortunately, the study had to be stopped at an inclusion rate of <10% because of difficulties in recruitment.

The DART study of low-dose dexamethasone therapy. The DART study of low-dose dexamethasone therapy Pediatrics. 2007 Sep;120(3):689-90; author reply 690-1. doi: 10.1542/peds.2007-1646. Authors Karin J Rademaker, Floris Groenendaal, Frank van Bel, Linda S de Vries, Cuno S P M Uiterwaal. PMID: 17766548 ...

To explore the minimum effective dose in ventilator-dependent infants born at <29 weeks, Cuna et al. compared two dexamethasone regimens: 27 patients received the DART regimen (0.89 mg/kg over 10 days) and 32 patients received a reduced version of …

Introduction: Determining the optimal dexamethasone dosage for facilitating extubation in extremely low birth weight (ELBW) infants with bronchopulmonary dysplasia (BPD) remains uncertain. This study aims to compare the effectiveness of low-dose (DART) and enhanced low-dose dexamethasone regimens in achieving successful extubation in these infants.

Oct 13, 2022 · The DART regimen treats select patients after surgery to 30 or 36 Gy over two weeks with two radiosensitizing doses of the chemotherapy docetaxel. Results of the initial clinical trial evaluating DART were published in the August 2019 issue of the Journal of Clinical Oncology, and reported a 98.7% overall survival rate at two years.

Oct 1, 2007 · The DART study was an international multicentre randomised controlled trial that had as its main aim to assess the effects of low-dose dexamethasone on long-term survival free of major neurologic...