DFX117 is a selective, orally active inhibitor for PI3Kα and c-Met tyrosine kinase. DFX117 inhibits PI3K/Akt/mTOR pathway, inhibits the proliferation of NCI-H1975, NCI-H1993, and HCC827 with IC50 s 0.02-0.08 µM. DFX117 arrests cell cycle at G0/G1 phase, induces apoptosis in A549 and NCI-H1975. DFX117 exhibits antitumor efficacy in mice.

(A) The proliferation of four lung cancer cell lines (A549, NCI-H1975, PC9 and NCI-H1993) were significantly inhibited by DFX117. (B) DFX117 showed few effects on cell growth of normal cell lines...

Weight Optimization: FiberX fiberglass bodywork is exceptionally lightweight, offering racers improved power-to-weight ratios. The reduction in weight allows for faster acceleration and greater agility on the track, giving racers a distinct competitive advantage.

May 5, 2019 · Concurrent targeted c-Met and PI3Kα by DFX117 dose-dependent inhibited the cell growth of H1975 cells (PIK3CA mutation and c-Met amplification) and A549 cells (KRAS …

DFX117 Cat. No.: HY-164384 CAS No.: 2125500-60-7 Molecular Formula: C26H26F2N6O5S Molecular Weight: 572.58 Target: PI3K; Akt; mTOR; Apoptosis Pathway: PI3K/Akt/mTOR ...

DFX-117|DFX 117: Drug Descriptions: DFX117 is a dual inhibitor that blocks Met and selectively inhibits Pik3ca kinase activity, which potentially results in inhibition of cell proliferation, and induction of cell cycle arrest and apoptosis (PMID: 31060329, PMID: 28800461). DrugClasses: MET Inhibitor 59 PIK3CA inhibitor 25: CAS Registry Number

Explore millions of resources from scholarly journals, books, newspapers, videos and more, on the ProQuest Platform.

SKU: DFX-117 Category: Fiberglass Bodywork. Share: Related products. Buell Pro Stock $ 229.95 – $ 595.95. View products. Harley-Davidson Fat Bob Tank Shell – Stretch $ 295.95. Add to cart. Harley-Davidson Superglide Fender Rear 8 7/8″ ...

Quantitative Proteomics Identifies DNA Repair as a Novel Biological Function for Hepatocyte Nuclear Factor 4α in Colorectal Cancer Cells