Oct 7, 2022 · Therefore, it is crucial to decipher the detailed molecular events involved in DNA damage responses (DDRs) to DNA-damaging agents in cancer. The tumor suppressor p53 is active at the hub of...

This review elucidates the complex interplay between p53 and the different DDR pathways and highlights its central and essential role in detecting DNA damage, signaling and executing appropriate cellular responses. The dual nature of p53 as a tumor suppressor and a key player in the DDR further highlights its importance in cancer biology.

The tumor suppressor p53 is active at the hub of the DDR. Researchers have identified an increasing number of genes regulated by p53 transcriptional functions that have been shown to be critical direct or indirect mediators of cell fate, cell cycle regulation, and DNA repair.

May 2, 2016 · Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can alter the functions of tumor suppressor genes or oncogenes, thus causing cancer development. As a central tumor suppressor, p53 guards the genome by orchestrating a variety of DNA-damage-response (DDR) mechanisms.

May 4, 2023 · The tumour suppressor p53 is a nuclear transcription factor with key roles during DNA damage to enable a variety of cellular responses including cell cycle arrest, apoptosis and DNA repair.

We report that endogenous p53 rapidly accumulates at DNA damage sites within 2 s of UVA microirradiation. The kinetics of p53 recruitment mimics those of known DNA damage-response proteins, such as Ku70 and poly (ADP-ribose) polymerase (PARP), and precedes recruitment of Nbs1, 53BP1, and DDB1.

In the DDR, p53 mRNA plays a pivotal role in p53 activation. Many RBPs, including transacting translation factors and microRNAs, were identified to bind multiple regions of p53 mRNA and regulate its translation.

New in-sights have recently been gained into the complexity of the p53 regulation of the DNA damage response (DDR) and how it impacts a wide variety of cellular pro-cesses. In addition to cell-autonomous signaling mechanisms, non-cell-autono-mous regulatory inputs influence p53 activity, which in turn can have systemic consequences on the organism.

Jan 20, 2025 · As a key regulator of the DNA damage response (DDR), p53 orchestrates several cellular processes, including cell cycle arrest, apoptosis, senescence, and autophagy [1,2,3], ensuring that damaged cells either repair themselves or undergo programmed cell death.

Jan 4, 2025 · To explore the potential mechanism, we focused on the impact of the ionizing radiation (IR)-induced DNA damage response (DDR), apoptosis, and senescence and the activation of the Daxx/MDM2/p53...