Jan 24, 2024 · We report that CCR7 + DCs are the dominant DC population that migrate to the dLN, but a subset remains tumour-resident despite CCR7 expression. These tumour-retained …

Abnormal expression of CCR7 in dendritic cells will cause a series of inflammatory diseases due to the chaotic dendritic cell trafficking. In this review, we take an in-depth look at the …

Jul 23, 2021 · CCR7 ligation in DCs induces complicated intracellular signaling pathways involving PI3K/AKT, MAPK/NF-κB, HIF-1α, and IRFs, which feedback to regulate the …

Aug 3, 2021 · In this review, we discuss the role of dendritic cells (DCs) and the central chemokine receptor CCR7 in the initiation and sustainment of selected chronic inflammatory …

Furthermore, CCR7 is the primary chemokine receptor that drives DC migration to the LN and, in turn, activates pathogenic T cells. Thus, antagonizing CCR7 at the ocular surface has been …

Jan 31, 2023 · Here we demonstrate that the Extl1 (Exostosin like glycosyltransferase 1) promotes CCR7-triggered DC migration in a heparan sulfate proteoglycans (HSPG) …

Aug 8, 2016 · Using multiple strategies, we identified a critical role for these DC in trafficking tumor antigen to lymph nodes (LN), resulting in both direct CD8 + T cell stimulation and …

Mar 19, 2019 · CCR7 chemokine receptor stimulation induces rapid but transient dendritic cell (DC) migration toward draining lymph nodes, which is critical for the initiation of protective …

Mar 15, 2011 · The importance for CCR7 expression on DC was shown by the complete failure of oral as well as respiratory tolerance induction in CCR7-deficient mice due to the lack of cellular …

Sep 1, 2023 · Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and ligand as part of the canonical GPCR desensitization response. …