Mar 28, 2025 · CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Diseases associated with CSNK1A1 include Enterobiasis and Amelogenesis Imperfecta, Type Iiia. Among its related pathways are CTNNB1 S33 mutants aren't phosphorylated and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene. [5]

May 24, 2018 · Casein kinase 1α (CK1α) (encoded by CSNK1A1 in humans) is a member of the CK1 family of proteins that has broad serine/threonine protein kinase activity [1, 2, 3, 4] (Fig. 1a) and is one of the main components of the Wnt/β-catenin signaling pathway.

Taken together, our study reveals a novel regulatory role of CSNK1A1 in the autophagic degradation of STING1 to maintain immune homeostasis. Manipulating CSNK1A1 through SSTC3 might be a potential therapeutic strategy for alleviating STING1-mediated aberrant type I IFNs in autoimmune diseases.

CSNK1A1/CK1alpha suppresses autoimmunity by restraining the CGAS-STING1 signaling. Selective CK1alpha degraders exert antiproliferative activity against a broad range of human cancer cell lines. Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.

Feb 8, 2025 · Enables protein serine/threonine kinase activity. Involved in several processes, including peptidyl-serine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of signal transduction. Located in cytoskeleton; cytosol; and nucleus. Part of beta-catenin destruction complex.

The Casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the common deleted region for del(5q) myelodysplastic syndrome (MDS). We generated a murine model with conditional inactivation of Csnk1a1 and found that Csnk1a1 ...

Jun 15, 2022 · In an academic-industry collaboration, we a) developed first-in-class potent and selective ATP-competitive CSNK1A1 small molecule inhibitors with preclinical anti-cancer efficacy in vivo, and b) identified FAM83 expression as a key determinant of inhibitor sensitivity.

Feb 18, 2025 · Enables protein serine/threonine kinase activity. Involved in negative regulation of NLRP3 inflammasome complex assembly and protein phosphorylation. Acts upstream of or within cell morphogenesis. Located in ciliary basal body and spindle. Part of ribonucleoprotein complex.

Casein kinase 1 alpha 1 (CK1α) (encoded on chromosome 5q by Csnk1a1) is considered an attractive target for Tp53 wild‐type acute myeloid leukaemia (AML) treatment. In this study, we evaluated the anti‐tumour effect of Csnk1a1 suppression in GBM cells in vitro and in vivo.