Jul 14, 2021 · In this review, we will discuss the enzymatic and non-enzymatic regulation of crotonylation, the cellular and physiological functions of Kcr, the cross-talk between Kcr with other PTMs, and the...

Sep 1, 2023 · Recent studies have hinted crotonylation is involved in the pathogenesis of various diseases. Future work needs to explore the specific regulatory factors and biological roles of crotonylation. Histone lysine crotonylation was first identified as a new type of post-translational modification in 2011.

Protein lysine crotonylation is a novel acylation modification discovered in 2011, which plays a key role in the regulation of various biological processes. Thousands of crotonylation sites have been identified in histone and non-histone proteins over the past decades.

Histone crotonylation is a newly identified epigenetic modification that has a pronounced ability to regulate gene expression. It belongs to an expanding group of short chain lysine acylations that also includes the extensively studied mark histone acetylation.

In recent studies, crotonylation was found to play a role in various diseases and biological processes. This paper reviews the initial discovery and regulatory mechanisms of crotonylation, including various writer, reader, and eraser proteins.

Apr 21, 2017 · Histone crotonylation specifically labels the enhancers and transcription starting sites of active genes in both the human somatic cell genome and the murine male germ cell genome. Histone...

Jul 1, 2024 · Proteins crotonylation is closely related to the occurrence and development of numerous diseases, including cancer, kidney diseases, and others. Crotonylation is an importantly conserved post-translational modification, which is completely different from acetylation.

Feb 24, 2017 · Bioinformatics analysis reveals that crotonylated proteins are particularly enriched for nuclear proteins involved in RNA processing, nucleic acid metabolism, chromosome organization, and gene expression.

Oct 15, 2023 · Among the present PTMs, crotonylation has emerged as a novel identified modification that is involved in a wide range of biological processes including gene expression, spermatogenesis, cell cycle, and the development of diverse diseases.

Mar 22, 2025 · For instance, CBP and hMOF strongly crotonylate non-histone NPM1, while PCAF exhibits moderate crotonylation activity . CBP catalyzes non-histone DDX5 Kcr, whereas p300, PCAF, and hMOF lack this activity . Lysine acetyltransferase 7 (KAT7) binds directly to calnexin, crotonylating its K525 site under leucine deprivation. This ...