Mar 30, 2025 · CRKL (CRK Like Proto-Oncogene, Adaptor Protein) is a Protein Coding gene. Diseases associated with CRKL include Digeorge Syndrome and Hemorrhage, Intracerebral. Among its related pathways are MET promotes cell motility and …

Crk-like protein is a protein that in humans is encoded by the CRKL gene. [5][6] v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion.

Recent structural work has identified new and unusual insights into the regulation of Crk proteins, providing a rationale for how Crk can sense diverse signals and produce a myriad of biological responses.

Sep 13, 2023 · Crk and Crkl are ubiquitously expressed genes encoding cytoplasmic adaptors essential for cell signaling. This study aims to explore the specific role of Crk and Crkl in the endocardial lineage during heart valve development. We deleted Crk and Crkl specifically in the endocardial lineage.

CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma. CRKL but not CRKII contributes to hemin-induced erythroid differentiation of CML. Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD.

Oct 28, 2013 · Crk and Crk-like (CrkL) cytosolic proteins have important roles in signal transduction from receptor tyrosine kinases and nonreceptor tyrosine kinase-coupled receptors to various downstream...

CRKL is a 39 kDa adapter protein, originally cloned in proximity to the BCR gene on chromosome 22, which has a key regulat-ory role in hematopoietic cells. CRKL has one SH2 and two SH3 domains,...

Feb 24, 2025 · Blood biomarkers have shown considerable promise in the diagnosis and prognosis of ischemic stroke. Serum markers, closely associated with stroke pathophysiology, aid in diagnosis, subtype identification, prediction of disease progression, early neurological deterioration, and recurrence.

May 8, 2019 · CRKL encodes a 303-amino acid polypeptide with a predicted molecular mass of 36 kD. While CRKL is not the human homolog of CRK, it is similar to protein-tyrosine kinases with SH2 and SH3 (src homology) domains.

May 13, 2012 · CrkL is a key signaling protein that mediates the leukemogenic activity of Bcr-Abl. CrkL is thought to adopt a structure that is similar to that of its CrkII homolog. The two proteins share...