Apr 21, 2020 · Collagen-producing cells maintain the complex architecture of the lung and drive pathologic scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all...

Jul 10, 2024 · Using whole-lung imaging, we found tdTomato + signals distributed diffusely throughout the alveolar region, whereas Col–GFP signals prominently highlighted bronchovascular bundles due to the...

Nov 24, 2023 · 胶原生成细胞 （Collagen-producing cells）维持肺的复杂结构并驱动肺纤维化的病理性瘢痕形成。 文章中进行scRNA-seq，以鉴定正常和纤维化肺中所有胶原生成细胞，在小鼠肺的不同隔室中具有不同解剖定位的多个胶原生成亚群的特征，一个以表达 「Cthrc1」 (collagen triple helix repeat containing 1) 为特征的亚群出现在纤维化肺中，表达最高水平的胶原。 作者把小鼠和人样本上传到一块了，这里我们先选取他们的小鼠样本来做复现。 只用GSM3891612 …

013134 B6.Cg-Tg (Col1a1*2.3-GFP)1Rowe/J This transgenic 2.3ColGFP mutant mouse strain expresses Green Fluorescent Protein in osteoblasts and osteocytes and may be useful in studies of bone development and osteoblast lineages.

Oct 20, 2018 · Because of its highly specific and physiologically accurate expression, our new Tg mouse line will help to accurately elucidate not only type I collagen-producing cells in normal tissues but also the potential cells in fibrotic tissues, providing new insights into the …

Our analysis of these GFP-expressing transgenic mice shows that the 2.3-kb promoter fragment directs strong expression of GFP only to bones and teeth, whereas the 3.6-kb fragment of promoter directs strong expression of GFP in bone and tooth, as well as in other type I collagen producing tissues.

In this study, we investigate the potential modulatory role of adult-specific collagen COL-19 in contact-mediated mate recognition. Our study shows that the expression of COL-19 ::GFP is adult-specific and not sexually dimorphic.

Col-GFP are a non-commercial murine HSC cell line that expresses GFP under the control of the Col1 promoter/enhancer and it is shown to be a suitable tool for investigating profibrogenic signal...

Nov 11, 2014 · Progressive fibrosis involves accumulation of activated collagen producing mesenchymal cells. Fibrocytes are hematopoietic-derived cells with mesenchymal features that potentially have a unique and critical function during fibrosis.

Oct 20, 2018 · To exclude the possibility of non-specific EGFP expression in the existing Tg mouse line and specifically monitor type I collagen-producing cells, we generated a new Tg mouse line and histologically confirmed the specificity of EGFP expression throughout the body.