Whether cloud seeding is effective in producing a statistically significant increase in precipitation is a matter of academic debate, with contrasting results depending on the study in question and contrasting opinion among experts.

A study conducted by the United States National Academy of Sciences failed to find statistically significant support for cloud seeding's effectiveness. Based on its findings, Stanford University ecologist Jerry Bradley said: "I think you can squeeze out a little more snow or rain in some places under some conditions, but that's quite different from a program claiming to reliably increase precipitation." Data similar to that of the NAS study was acquired in a separate study conducted by the Wyoming Weather Modification Pilot Project, but whereas the NAS study concluded that "it is difficult to show clearly that cloud seeding has a very large effect", the WWMPP study concluded that "seeding could augment the snowpack by a maximum of 3% over an entire season."

In 2003, the US National Research Council (NRC) released a report stating, "science is unable to say with assurance which, if any, seeding techniques produce positive effects. In the 55 years following the first cloud-seeding demonstrations, substantial progress has been made in understanding the natural processes that account for our daily weather. Yet scientifically acceptable proof for significant seeding effects has not been achieved".

A 2010 Tel Aviv University study claimed that the common practice of cloud seeding to improve rainfall, with materials such as silver iodide and frozen carbon dioxide, seems to have little if any impact on the amount of precipitation. A 2011 study suggested that airplanes may produce ice particles by freezing cloud droplets that cool as they flow around the tips of propellers, over wings or over jet aircraft, and thereby unintentionally seed clouds. This could have potentially serious consequences for particular hail stone formation.

In 2016, Jeff Tilley, director of weather modification at the Desert Research Institute in Reno, claimed that new technology and research has produced reliable results that make cloud seeding a dependable and affordable water supply practice for many regions. Moreover, in 1998 the American Meteorological Society held that "precipitation from supercooled orographic clouds (clouds that develop over mountains) has been seasonally increased by about 10%."

Despite the mixed scientific results, cloud seeding was attempted during the 2008 Summer Olympics in Beijing to coax rain showers out of clouds before they reached the city in order to prevent rain during the opening and closing ceremonies. Whether this attempt was successful is a matter of dispute, with Roelof Bruintjes, who leads the National Center for Atmospheric Research's weather-modification group, remarking, "we cannot make clouds or chase clouds away".

With an NFPA 704 health hazard rating of 2, silver iodide can cause temporary incapacitation or possible residual injury to humans and other mammals with intense or chronic exposure. But several detailed ecological studies have shown negligible environmental and health impacts. The toxicity of silver and silver compounds (from silver iodide) was shown to be of low order in some studies. These findings likely result from the minute amounts of silver generated by cloud seeding, which are about one percent of industry emissions into the atmosphere in many parts of the world, or individual exposure from tooth fillings.

Accumulations in the soil, vegetation, and surface runoff have not been large enough to measure above natural background. A 1995 environmental assessment in the Sierra Nevada of California and a 2004 independent panel of experts in Australia confirmed these earlier findings.

"In 1978, an estimated 3,000 tonnes of silver were released into the US environment. This led the US Health Services and EPA to conduct studies regarding the potential for environmental and human health hazards related to silver. These agencies and other state agencies applied the Clean Water Act of 1977 and 1987 to establish regulations on this type of pollution."

Cloud seeding over Kosciuszko National Park – a biosphere reserve – is problematic in that several rapid changes of environmental legislation were made to enable the trial. Environmentalists are concerned about the uptake of elemental silver in a highly sensitive environment affecting the pygmy possum, among other species, as well as recent high-level algal blooms in once pristine glacial lakes. Research 50 years ago and analysis by the former Snowy Mountains Authority led to the cessation of the cloud seeding program in the 1950s with non-definitive results. Formerly, cloud seeding was rejected in Australia on environmental grounds because of concerns about the pygmy possum. The claims of negative environmental impact are disputed by peer-reviewed research, as summarized by the International Weather Modification Association.

In 1891, Louis Gathmann suggested shooting liquid carbon dioxide into rain clouds to cause them to rain. During the 1930s, the Bergeron–Findeisen process theorized that supercooled water droplets present, while ice crystals are released into rain clouds, would cause rain. While researching aircraft icing, General Electric (GE)'s Vincent Schaefer and Irving Langmuir confirmed the theory. Schaefer discovered the principle of cloud seeding in July 1946 through a series of serendipitous events. Following ideas he and Langmuir generated while climbing Mt. Washington in New Hampshire, Schaefer, Langmuir's research associate, created a way of experimenting with supercooled clouds using a deep freeze unit of potential agents to stimulate ice crystal growth, i.e., table salt, talcum powder, soils, dust, and various chemical agents with minor effect. Then, on July 14, 1946, he wanted to try a few experiments at GE's Schenectady Research Lab.

He was dismayed to find that the deep freezer was not cold enough to produce a "cloud" using breath air. He decided to move the process along by adding a chunk of dry ice just to lower the temperature of his experimental chamber. To his astonishment, as soon as he breathed into the deep freezer, he noted a bluish haze, followed by an eye-popping display of millions of microscopic ice crystals, reflecting the strong light rays from the lamp illuminating a cross-section of the chamber. He instantly realized that he had discovered a way to change super-cooled water into ice crystals. The experiment was easily replicated, and he explored the temperature gradient to establish the −40 °C (−40 °F) limit for liquid water.

Within the month, Schaefer's colleague, the atmospheric scientist Bernard Vonnegut, was credited with discovering another method for "seeding" super-cooled cloud water. Vonnegut accomplished his discovery at the desk, looking up information in a basic chemistry text and then tinkering with silver and iodide chemicals to produce silver iodide. Together with Professor Henry Chessin, of SUNY Albany, a crystallographer, he co-authored a publication in Science and received a patent in 1975. Both methods were adopted for use in cloud seeding during 1946 while working for GE in the state of New York.

Schaefer's method altered a cloud's heat budget; Vonnegut's altered formative crystal structure, an ingenious property related to a good match in lattice constant between the two types of crystal. (The crystallography of ice later played a role in Vonnegut's brother Kurt Vonnegut's novel Cat's Cradle). The first attempt to modify natural clouds in the field through "cloud seeding" began during a flight that began in upstate New York on 13 November 1946. Schaefer was able to cause snow to f…

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