Clathrin is a protein that plays a role in the formation of coated vesicles. Clathrin was first isolated by Barbara Pearse in 1976. [1] It forms a triskelion shape composed of three clathrin heavy chains and three light chains.

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. This review describes the structures of clathrin, major ...

Feb 7, 2018 · Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide range of cargo molecules from the cell surface to the interior.

Clathrin is an intracellular protein present in the cytosol of eukaryotic cells. When recruited to the cytosolic surface of the plasma and intracellular membranes, clathrin can self-assemble into a polyhedral lattice.

Clathrin is a cytosolic protein involved in the intracellular trafficking of a wide range of cargo. It is composed of three heavy chains and three light chains that together form a triskelion, the subunit that polymerizes to form a clathrin coated vesicle.

Jul 22, 2011 · Clathrin-mediated endocytosis is a modular process that involves core and accessory adaptor proteins that package cargoes into vesicles, ultimately leading to their uptake.

Clathrin was discovered nearly 25 years ago. Since then, a large number of other proteins that participate in the process by which clathrin-coated vesicles retrieve synaptic membranes or take up endocytic receptors have been identified.

Aug 27, 2021 · Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or …

May 15, 2006 · In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin lattice and discovery of a …

Clathrin is the prototype self-assembling protein that coats transport vesicles during membrane traffic. Its ability to polymerize into a polyhedral lattice contributes to organization and sorting of integral membrane proteins during receptor-mediated endocytosis, organelle biogenesis, and selected recycling pathways and degradation pathways.