Conjunctival intraepithelial neoplasia (CIN) is noninvasive by definition; the basement membrane remains intact and the underlying substantia propria is spared. It is a slow-growing tumor that arises from a single mutated cell on the ocular surface.

Conjunctival intraepithelial neoplasia could be a fleshy, sessile or minimally elevated lesion that frequently appears perilimbal in the interpalpebral zone, or less commonly in the inferior fornix or palpebral conjunctiva. CIN can extend into the adjacent corneal epithelium.

Sep 15, 2016 · CIN is an abnormal line of conjunctival (and possibly corneal) epithelial cells and represents either simple dysplasia (partial thickness of epithelial tissue) or carcinoma in situ when the lesion is full thickness. 1-4 CIN is part of the spectrum of neoplastic disorders of the conjunctiva and cornea known collectively as ocular surface ...

Mar 1, 2012 · Ocular surface squamous neoplasia (OSSN) comprises a wide spectrum of dysplastic changes to the epithelium of the cornea, limbus and conjunctiva. These changes include corneal and conjunctival intraepithelial neoplasia …

May 15, 2019 · The general clinical term of OSSN includes a spectrum of malignancies that ranges from mild epithelial dysplastic changes, such as conjunctival intraepithelial neoplasia (CIN), to more severe invasive carcinoma that invades through the basement membrane into the substantia propria, such as squamous cell carcinoma.

Patients notice a white or yellow-white tumor on the surface of the eye (often with extension onto the cornea). Diagnosis. Squamous conjunctival neoplasia tends to be found between the eyelids (interpalpebral space), and at the limbus (border of the white sclera and clear cornea).

Jun 21, 2024 · Conjunctival intraepithelial neoplasia is characterized by a proliferation of neoplastic squamous cells showing cellular atypia. It is considered a premalignant lesion that may progress to invasive squamous cell carcinoma. HPV 6 and 11 (choice A) are associated with squamous papilloma.

Enlarged: Conjunctival intraepithelial neoplasia (CIN) with full thickness dysplasia (squamous cell carcinoma in situ) A 68-year-old male patient presented for a routine cataract evaluation and was found to have a suspicious conjunctival lesion in the left eye.

Tumors were classified into 4 histological groups: conjunctival intraepithelial neoplasia (CIN) with mild dysplasia (grade 1/3), moderate dysplasia (grade 2/3), severe dysplasia (grade 3/3 or carcinoma in situ), and invasive squamous cell carcinoma (SCC).

Jan 1, 2011 · Conjunctival intraepithelial neoplasia (CIN) is the most common tumor of the ocular surface and is a precursor to invasive squamous cell carcinoma. CIN comprises a spectrum of premalignant epithelial neoplasia that usually begins near the limbus and spreads to the cornea.