Chymases (EC 3.4.21.39, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in …

Chymase-expressing mast cells are abundant in skin, and it is therefore reasonable to assume that chymase could have a significant impact on pathologies of this organ. Indeed, there are numerous studies in support of this notion.

Jan 19, 2018 · Chymase is the most efficient Ang II (angiotensin II)–forming enzyme in the human body and has been implicated in a wide variety of human diseases that also implicate its many other protease actions.

Chymase is a chymotrypsin-like neutral protease that is found in a specific subset of human mast cells. It has the ability to cleave matrix components and activate enzymes involved in matrix remodeling. Additionally, chymase can activate angiotensin I, leading to the independent activation of angiotensin II.

Chymase is a chymotrypsin-type serine protease mainly localized in mast cells (MCs). Human, primate, and dog chymase generate angiotensin II (Ang II) from Ang I, while mouse and rat chymases degrade Ang II.

Jan 19, 2018 · Chymase is the most efficient Ang II (angiotensin II)-forming enzyme in the human body and has been implicated in a wide variety of human diseases that also implicate its many other protease actions.

In this review, we discussed the current state of knowledge about mast cell chymase as one of the mast cell secretome proteases. Main issues of the reviewed publications are highlighted with our microscopic images of mast cell chymase visualized using immunohistochemical staining.

Befitting their greater destructive potential, chymases are quickly inhibited after release, although some gain protection by associating with proteoglycans. Most chymase-like enzymes, including mast cell cathepsin G, hydrolyze chymotryptic substrates, an uncommon capability in …

Chymase is the most efficient angiotensin II-forming enzyme in the human body and has been implicated in a wide variety of human diseases that also implicate its many other protease actions.

Nov 18, 2009 · This study explores the hypothesis that intrarenal angiotensin II can be generated from angiotensinogen by either of two pathways: a conventional ACE-dependent mechanism, and alternatively by an ACE-independent pathway, likely mediated by chymase.