Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene. [ 5 ] [ 6 ] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily.

Celsr3 knockdown with RNAi increases rather than decreases dendrite length. In addition to its inhibitory role in dendrite growth, Celsr3 is essential for axon guidance. Celsr3 mutant mice exhibit multi-faceted defects in the development of axonal tracts and anterior-posterior guidance defects in the brainstem ( Tissir et al. 2005 ...

Mar 30, 2025 · CELSR3 (Cadherin EGF LAG Seven-Pass G-Type Receptor 3) is a Protein Coding gene. Diseases associated with CELSR3 include Hirschsprung Disease 1 and Congenital Anomalies Of Kidney And Urinary Tract 1. Among its related pathways is GPCRs, other.

CELSR3, a crucial signalling molecule in the WNT/PCP pathway, is believed to be associated with tumorigenesis and metastasis. However, its role in lung adenocarcinoma (LUAD) remains unclear. In this paper, we analysed the expression of CELSR family members using the Oncomine, GEPIA and UALCAN databases.

The present study aimed to investigate the clinical value and functional role of CELSR3 in hepatocellular carcinoma (HCC), and determine the underlying molecular mechanism in patients with HCC. CELSR3 expression in tumor and paracancerous HCC tissues was obtained from The Cancer Genome Atlas.

Jun 27, 2023 · Here, we investigate G protein induction principles of aGPCRs using mammalian latrophilin 3 (LPHN3) and cadherin EGF LAG-repeat 7-transmembrane receptors 1–3 (CELSR1–3), members of two aGPCR families conserved from invertebrates to vertebrates.

Jan 5, 2025 · CELSR3 is a prognostic marker in HNSCC and correlates with immune cell infiltration in the tumor microenvironment. Involvement of CELSR3 Hypermethylation in Primary Oral Squamous Cell Carcinoma. Khor GH, Froemming GR, Zain RB, Abraham TM, Lin TKKhor GH, et al. Asian Pac J Cancer Prev, 2016. PMID 26838213.

Aug 3, 2023 · CELSR3 was found to be overexpressed in NEPC compared with CRPC, prostate cancer, and benign tissue . CELSR3 is part of the larger adhesion-class G protein-coupled receptors. It contains large extracellular domains which are cleaved autoproteolytically at a conserved GPS within the GAIN domain.

Jul 23, 2021 · Atypical cadherin Celsr3 is critical for brain embryonic development, and its role in the postnatal cerebellum remains unknown. Using Celsr3-GFP mice, Celsr3 shows high expression in postnatal Purkinje cells (PCs).

CELSR3 promoter hypermethylation is associated with oral squamous cell carcinoma. CELSR3 was found to be selectively up-regulated in tumor stellate cells. CELSR3 is one of the core PCP signaling molecules.