CDT1 (Chromatin licensing and DNA replication factor 1) is a protein that in humans is encoded by the CDT1 gene. [5] [6] [7] [8] It is a licensing factor that functions to limit DNA from replicating more than once per cell cycle.

Mar 30, 2025 · CDT1 (Chromatin Licensing And DNA Replication Factor 1) is a Protein Coding gene. Diseases associated with CDT1 include Meier-Gorlin Syndrome 4 and Meier-Gorlin Syndrome 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Activation of the pre-replicative complex.

Dec 22, 2016 · The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is also required during mitosis. Tight cell cycle controls over Cdt1 abundance and activity are critical to normal development and genome stability.

Feb 8, 2025 · Cdt1 is phosphorylated and its degradation induced by Cdk2 and Cdk4; human CDT1 is essential for DNA replication and chromatin licensing; Cdt1 overexpression contributes to tumorigenecity by causing genomic instability in transgenic p53 knockout mice.

In this review we summarize structural studies of Cdt1 and Geminin and subsequent insights into how this molecular switch may function to ensure DNA is faithfully replicated only once during S phase of each cell cycle.

Jan 1, 2007 · Cdt1 is regulated over the course of the cell cycle mainly by the controlled expression of an inhibitor protein, geminin, and the level of Cdt1 periodically fluctuates due to ubiquitination and proteolysis.

The CDT1 gene provides instructions for making a protein that is important in the copying of a cell's DNA before the cell divides (a process known as DNA replication). Learn about this gene and related health conditions.

Indeed, Cdt1 overexpression evokes chromosomal damage even without re-replication. Furthermore, deregulated Cdt1 induces chromosomal instability in normal human cells. Since Cdt1 is overexpressed in cancer cells, this could be a …

Jan 5, 2023 · Cells must avoid licensing of neosynthesized DNA to prevent rereplication. In this issue of Molecular Cell, Ratnayeke et al. (2022) 1 reveal how the licensing factor CDT1, prior to its degradation, inhibits DNA elongation by suppressing CMG …

Dec 3, 2023 · Title: Elevated expression of CDT1 in childhood acute lymphoblastic leukemia promotes cell proliferation, invasion and migration through activation of EMT. Successful pregnancies in an adult with Meier-Gorlin syndrome harboring biallelic CDT1 variants.