Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. [5]

Mar 30, 2025 · CDK1 (Cyclin Dependent Kinase 1) is a Protein Coding gene. Diseases associated with CDK1 include Retinoblastoma and Breast Cancer. Among its related pathways are Loss of Nlp from mitotic centrosomes and CDK-mediated phosphorylation and removal of Cdc6.

Jun 13, 2023 · Deregulation of CDK1 has been shown to be closely associated with tumorigenesis. CDK1 activation plays a critical role in a wide range of cancer types; and CDK1 phosphorylation of its many...

Feb 9, 2025 · cyclin-dependent kinase 1 (Cdk1), a known target of E2F1, is involved in G1 checkpoint regulation, as Cdk1 knockdown hindered G1/S progression, while Cdk1 overexpression rescued RCC1 knockdown-mediated effect on G1 cell cycle progression.

Oct 28, 2023 · CDK1, the first identified member of the Cdk family, is conserved in all organisms and regulates the transition between the G2 phase and mitosis. The activity of CDK1 is modulated by its...

One of these genes called “START” (later known as CDK1) played a crucial role in regulating the first step of each cell cycle. Next, Nurse P. M. identified and characterized cyclin-dependent kinases (CDKs) and showed that CDK drives the cell cycle by phosphorylating other proteins.

CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and is conserved across all eukaryotes. Here we report the crystal structures of complexes of CDK1–Cks1 and …

The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle. However, studies conducted several ...

May 13, 2010 · In this review we discuss currently known targets of Cdk1 in the budding yeast S. cerevisiae and highlight the role of Cdk1 in several crucial processes including maintenance of genome stability. In eukaryotic cells, the cell cycle is controlled by …

here we describe how CDK1 alone or in complex with cyclin B1 controls crucial ‘unconventional’ biological functions through the phosphorylation of a highly connected signalling network (Fig. 2d).