The common gamma chain (γ c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, [5] IL-7, [6] IL-9, IL-15 [7] and interleukin-21 receptor.

Nov 17, 2024 · CD132, also known as IL-2RG or common γ chain (γc) cytokine receptor, is the common subunit of γc cytokines, including interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and...

Mar 15, 2001 · IL-2R is made up of three chains, α (CD25), β (CD122), and γ (CD132), of which only the α-chain is specific for IL-2. Signaling takes place mainly via CD122. Activated T cells express the high affinity receptor composed of all three chains (22).

IL-2 and its receptor have key roles in key functions of the immune system, tolerance and immunity, primarily via their direct effects on T cells.

Mar 17, 2025 · IL-2 signaling begins when the cytokine binds its receptor complex, triggering intracellular events that regulate proliferation, survival, and gene expression. JAK1 associates with the beta subunit (CD122), while JAK3 binds the gamma subunit (CD132), forming a signaling-competent receptor complex.

CD132，又称为共用γ链（Common gamma chain，缩写γ c)，白介素2受体γ亚基（interleukin-2 receptor subunit gamma，缩写IL-2RG）是一种细胞因子受体亚基，存在于至少六种不同的白介素受体中：包括IL-2、IL-4 [7] 、IL-7 [8] 、IL-9、IL-15 [9] 和IL-21的受体。

Recent studies have shown that a wide range of membrane proteins have labile disulfide bonds including CD132, the common gamma chain of the receptors for several cytokines including interleukin-2 and interleukin-4 (IL-2 and IL-4).

Jan 15, 2015 · We observed that anti-CD132 monoclonal antibody (mAb) reduced acute GVHD potently with respect to survival, production of tumor necrosis factor, interferon-γ, and IL-6, and GVHD histopathology. Anti-CD132 mAb afforded protection from GVHD partly via inhibition of granzyme B production in CD8 T cells, whereas exposure of CD8 T cells to IL-2, IL ...

Common γ-chain cytokines increase granzyme B levels in CD8 T cells, which are reduced upon CD132 blockade in vivo. The common γ chain (CD132) is a subunit of the interleukin (IL) receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21.

Mar 15, 2001 · The expression of the IL-2R alpha-, beta-, and gamma-chains, CD25, CD122, and CD132, respectively, was investigated on fibroblast-like synoviocytes (FLS) and dermal fibroblasts (DF). Both protein and mRNA for CD122 and CD132 were observed but there was no evidence of CD25 expression.