Most studies investigating catenin actions have focused on α-catenin and β-catenin. β-catenin is particularly interesting as it plays a dual role in the cell. First of all, by binding to cadherin receptor intracellular cytoplasmic tail domains, [ 10 ] it can act as an integral component of a protein complex in adherens junctions that helps ...

Jan 3, 2022 · The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis.

β-Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule that in metazoans exerts a crucial role in a multitude of developmental and homeostatic processes. More specifically, β-catenin is an integral structural ...

Members of the catenin family were first isolated complexed with the cytoplasmic domains of cadherins at cell-cell junctions, and this relationship is considered one of the defining aspects of catenins. Their functions at such contacts are multifaceted and …

Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. β-Catenin is a dual function protein , involved in regulation and coordination of cell–cell adhesion and gene transcription .

Signaling by the Wnt family of secreted glycolipoproteins via the transcription co-activator β-catenin controls embryonic development and adult homeostasis. Here we review recent progresses in this so-called canonical Wnt signaling pathway. We ...

CT and ultrasound imaging of the abdomen exhibited a solid and cystic tumor measuring 8 cm near the tail of the pancreas. Tumor cells were positive for beta catenin, CD10, CD56, CD117 and cyclin D1. Beta catenin was expressed in the nucleus of tumor cells.

Catenin is a protein that plays a dual role in intercellular adhesion and transcriptional regulation. It facilitates the binding of cadherins to the actin cytoskeleton and activates target genes of the Wnt signaling pathway. The functions of catenin are crucial for various developmental processes, such as stem cell proliferation and ...

Jan 24, 2025 · Although a simple model describing Wnt–β-catenin signalling is widely used to introduce this pathway and has largely remained unchanged over the past 30 years, in this Review we discuss...

Jan 24, 2025 · Defects in canonical Wnt signalling, which is transduced intracellularly by β-catenin, have been associated with developmental disorders, degenerative diseases and cancers.