CYP1B1 belongs to the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.

The CYP1B1 gene provides instructions for producing an enzyme that is a member of the cytochrome P450 family of enzymes. Learn about this gene and related health conditions.

Mar 30, 2025 · CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a Protein Coding gene. Diseases associated with CYP1B1 include Glaucoma 3, Primary Congenital, A and Anterior Segment Dysgenesis 6. Among its related pathways are Fatty acid metabolism and Metapathway biotransformation Phase I and II.

CYP1B1 is a member of the CYP1 subfamily of CYP superfamily of enzymes, which contains three members, CYP1A1, CYP1A2, and CYP1B1. CYP1B1 is expressed in both adult and fetal human extrahepatic tissues, including the parenchymal and stromal cells of most organs.

Cytochrome P450 1B1 (CYP1B1), a member of CYP450s, is expressed in liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including the metabolic activation of polycyclic aromatic hydrocarbons.

Feb 15, 2024 · Learn how the CYP1B1 gene impacts estrogen metabolism and whether variants in CYP1B1 gene increase the risk for breast cancer.

In this review, we discuss the growing body of evidence suggesting that inhibition of the cytochrome P450 1B1 enzyme (CYP1B1) can be a promising therapeutic strategy that has the potential to prevent cancer treatment-induced cardiovascular complications without reducing their anti-cancer effects.

Gene ID: 1545, updated on 8-Feb-2025. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of …

CYP1B1, a recently described dioxin inducible oxidoreductase, is a member of the cytochrome P450 superfamily involved in the metabolism of estradiol, retinol, benzo [a]pyrene, tamoxifen, melatonin, sterols etc.

CYP1B1 represents a promising biomarker and therapeutic target because it is overexpressed in several types of cancer, is involved in drug-resistance, activates a number of procarcinogenic compounds and catalyzes the conversion of E2 to 4-hydroxy-E2, a mutagenic compound.