Visualization of crystallized protein CXCL14. Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine). [1]

Jan 5, 2016 · CXCL14, a relatively novel chemokine, is a non-ELR (glutamic acid-leucine-arginine) chemokine with a broad spectrum of biological activities. CXCL14 mainly contributes to the regulation of immune cell migration, also executes antimicrobial immunity.

Mar 30, 2025 · CXCL14 (C-X-C Motif Chemokine Ligand 14) is a Protein Coding gene. Diseases associated with CXCL14 include Cervical Squamous Cell Carcinoma and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are MIF Mediated Glucocorticoid Regulation and ERK Signaling.

The chemokine CXCL14 is a highly conserved, homeostatic chemokine which is constitutively expressed in skin epithelia. Responsible for immune cell recruitment and maturation, as well as impacting epithelial cell motility, CXCL14 contributes to the ...

CXCL14 inhibits colorectal cancer migration, invasion, and epithelial-to-mesenchymal transition (EMT) by suppressing NF-kappaB signaling. Downregulation of CXCL14 expression is associated with gastric adenocarcinoma. CXCL14 plays a pivotal role as a potential tumor suppressor in hepatocellular carcinoma.

A recent study indicated that CXCL14 regulates the development of the microglia in the early cortex, and it is important for cell localization in early cortical stages . CXCL14 is expressed in GABAergic interneurons of the adult mouse dentate gyrus and inhibits GABAergic transmission to neural stem cells [6,7].

Jan 6, 2024 · Patients with idiopathic pulmonary fibrosis show a strongly upregulated expression of chemokine CXCL14, whose target is still unknown. Screening of CXCL14 in a panel of human G protein-coupled...

Oct 10, 2015 · Among the 45 or so members of this family, CXCL14, also named BRAK for its initial isolation from breast and kidney, has a particular status because it is an orphan chemokine for which no receptor has been unequivocally identified.

As a member of the CXC subfamily of chemokines, CXCL14 is responsible for the infiltration of immune cells, maturation of dendritic cells, upregulation of major histocompatibility complex (MHC)-I expression, and cell mobilization.

Many previous studies have shown how chemokine signaling pathways could be targeted to halt cancer progression. We and others have revealed that the chemokine CXCL14 promotes antitumor immune responses, suggesting that CXCL14 may be effective for cancer immunotherapy.