CXCL13 is a small chemokine belonging to the CXC chemokine family. As its other names suggest, this chemokine is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5.

CXCL13 is a chemokine that plays an important role in the regulation and development of secondary lymphoid organs. CXCL13 is also involved in the regulation of pathological processes, particularly inflammatory responses, of many diseases. The ...

Mar 30, 2025 · CXCL13 (C-X-C Motif Chemokine Ligand 13) is a Protein Coding gene. Diseases associated with CXCL13 include Angioimmunoblastic T-Cell Lymphoma and Central Nervous System Lymphoma . Among its related pathways are MIF Mediated Glucocorticoid Regulation and GPCR downstream signalling .

Jul 19, 2021 · It is well-established that the chemokine C-X-C motif ligand 13 (CXCL13) and its receptor, the G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory, infectious and immune responses. Originally identified as a B-cell ...

CXCL13/CXCR5-associated immune activities orchestrate highly specific B cell–T cell interactions required for protective high-affinity antibody responses in SLO, their balance being of utmost relevance for infection control and prevention of autoimmunity.

Feb 8, 2025 · CXCL13 chemokine is a novel player in multiple myeloma osteolytic microenvironment, M2 macrophage polarization, and tumor progression. CXCL13 is elevated in inflammatory bowel disease in mice and humans and is implicated in disease pathogenesis.

Sep 13, 2021 · By interacting with the CXCR5 receptor, CXCL13 facilitated vascular endothelial growth factor (VEGF) expression and angiogenesis in EPC through the PLC, MEK, and AP-1 signaling pathways.

Jul 22, 2020 · Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes forms both soluble and immobilized gradients...

Nov 15, 2004 · Recently recruited and mature macrophages express CXCL13 that is also associated with extracellular fibrils. Single exposures of multicolor immunofluorescence staining for CXCL13 and various markers (see keys) in inflammatory lesions or germinal centers of normal lymphoid tissue.

Jul 12, 2019 · Originally identified as a B-cell chemoattractant, CXCL13 exerts important functions in lymphoid neogenesis, and has been widely implicated in the pathogenesis of a number of autoimmune diseases and inflammatory conditions, as well as in lymphoproliferative disorders.