Casein kinase 1 and Wnt/β-catenin signaling - PubMed
Casein kinase 1 (CK1) members play a critical and evolutionary conserved role in Wnt/β-catenin signaling. They phosphorylate several pathway components and exert a dual function, acting …
Casein Kinase 1α as a Regulator of Wnt-Driven Cancer - PMC
We then discuss the roles of the established negative Wnt regulator, casein kinase 1α (CK1α), in Wnt signaling. Although the study of CK1α has been ongoing for several decades, the bulk of …
Wnt signaling inhibits casein kinase 1α activity by modulating its ...
Feb 25, 2025 · As CK1α is a crucial negative regulator of Wnt signaling, we generated two clonal HEK293FT cell lines with the CK1α T321A mutation knocked in in order to probe the role of …
Unwinding the Wnt action of casein kinase 1 - PMC
How does CK1 accomplish so many different jobs in the Wnt pathway and how is it controlled? A key mechanism for regulation is CK1s' differential interaction with scaffolds and membranes. …
CK1 in Developmental signaling: Hedgehog and Wnt - PMC
Multiple CK1 family members regulate both Hh and Wnt signaling, and in each pathway, CK1 exerts both positive and negative influences depending on the signaling status, the specific …
Coordinated action of CK1 isoforms in canonical Wnt signaling
In this report, we have dissected the roles of CK1 isoforms in the early steps of Wnt signaling. CK1ε is constitutively bound to LRP5/6 through its interaction with p120-catenin and E …
Casein kinase 1 - Wikipedia
The Casein kinase 1 family (EC 2.7.11.1) of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell …
Casein kinase 1 and Wnt/β-catenin signaling - ScienceDirect
Dec 1, 2014 · Casein kinase 1 (CK1) members play a critical and evolutionary conserved role in Wnt/β-catenin signaling. They phosphorylate several pathway components and exert a dual …
CK1 in Developmental Signaling: Hedgehog and Wnt - PubMed
Hedgehog (Hh) and Wnt pathways are two major and evolutionarily conserved signaling pathways that control embryonic development and adult tissue homeostasis. Deregulation of these …
Unwinding the Wnt action of casein kinase 1 | Cell Research
Apr 9, 2013 · A recent study published in Science identifying allosteric activation of CK1 by the DEAD-box RNA helicase DDX3 expands our understanding of the control of this abundant …