Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15 INK4b is a protein that is encoded by the CDKN2B gene in humans. [5] [6]

Mar 30, 2025 · CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) is a Protein Coding gene. Diseases associated with CDKN2B include Multiple Endocrine Neoplasia, Type Iv and Coronary Artery Anomaly. Among its related pathways are Gene …

Nov 23, 2015 · Microarray studies identified impaired transforming growth factor β (TGF β) signaling in cultured cyclin-dependent kinase inhibitor 2B (CDKN2B)–deficient cells, as well as TGF β 1 upregulation in the vasculature of 9p21 risk allele carriers.

Mar 16, 2025 · Title: Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular lymphoma is related to duodenal reactive lymphoid hyperplasia.

Sep 11, 2017 · In this study, we demonstrate that inactivation of Cdkn2b (p15ink4b) is necessary for induction of pancreatic cancer by oncogenic KRAS G12D expression and inactivation of Tp53 and Cdkn2a in adult...

Jan 22, 2016 · Microarray studies identified impaired transforming growth factor β (TGFβ) signaling in cultured cyclin-dependent kinase inhibitor 2B (CDKN2B)-deficient cells, as well as TGFβ1 upregulation in the vasculature of 9p21 risk allele carriers.

Microarray studies identified impaired TGFβ signaling in cultured CDKN2B -deficient cells, as well as TGFβ1 upregulation in the vasculature of 9p21 risk allele carriers. Molecular signaling studies indicated that loss of CDKN2B impairs the expression of the inhibitory factor, SMAD-7, which promotes downstream TGFβ activation.

Jan 5, 2025 · This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression.

Apr 6, 2021 · The potency of CDKN2B/p15 INK4B in tumor suppression relies on its strong binding via key N-terminal residues to and inhibition of CDK4/CDK6. p15 INK4B also binds and inhibits enolase-1, a...

CDKN2B; cyclin dependent kinase inhibitor 2B. Aliases: P15, MTS2, TP15, CDK4I, INK4B, p15INK4b. Location: 9p21.3. Summary: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors.