Overexpression of cell cycle-related genes CDKN2A, CDK1, CCNE1, and their gene network may help elucidate the pathogenic pathway of SGC of the eyelid at the molecular level.

The loss of CDKN2A appears to be closely related to the functional inactivation of CDKN1B, and assessment of CDKN1A status may be useful for a precise prognostic prediction of individuals with HCC expressing high levels of CDKN1B .

Sep 30, 2019 · Gene networks of CDKN2A, CDK1, and CCNE1 include cell cycle progression, incidence of tumor, and cell viability identified by upregulated genes in patients with SGC of the eyelid. These networks were analyzed using the Ingenuity pathway analysis tools.

CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. [5] It is ubiquitously expressed in many tissues and cell types. [6] The gene codes for two proteins, including …

Mining therapeutic sensitivities shows that there are reciprocal vulnerabilities associated with RB1 or CCND1 expression versus CCNE1 or CDKN2A. Together, these findings illustrate the complex nature of cancer cell cycles and the relevance for precision therapeutic intervention.

Dec 17, 2024 · Restoring p16 in cell lines harboring CDKN2A/p16 genomic deletions alleviated Cdk2 activation and replication stress, attenuating CHKi hypersensitivity. Taken together, our results suggest a biomarker-driven strategy for selecting HNSCC patients who may benefit the most from CHKi therapy.

Gene networks of CDKN2A, CDK1, and CCNE1 include cell cycle progression, incidence of tumor, and cell viability identified by upregulated genes in patients with SGC of the eyelid.

Nov 4, 2024 · CDKN2A, a critical tumor suppressor gene, is significantly overexpressed in CSCC, encoding p16 and p14ARF growth inhibitors. High-risk HPV oncoproteins inactivate p53 and pRb, potentially triggering CDKN2A overexpression, which may serve as a consistent genetic anomaly and biomarker in cervical cancer, particularly through p16 [ 19 ].

Dec 24, 2024 · CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) is a Protein Coding gene. Diseases associated with CDKN2A include Melanoma, Cutaneous Malignant 2 and Melanoma-Pancreatic Cancer Syndrome.

Mar 1, 2007 · In humans, CDKN1A, CDKN1B and CDKN1C (p57) are differentially expressed in normal versus atherosclerotic vessels. A DNA-polymorphism within the CDKN1B promoter has been associated with myocardial infarction (MI). In the present study, we analyzed the effect of CDKN1A, CDKN1C and CDKN2A (p16) polymorphisms on MI-risk.