Cdc42 regulates the pathogenesis of DN by (a) promoting podocyte injury through interacting with some receptors and enzymes (such as TGF-β, SRGAP2a, PI3K, PTEN, and NMDARs); (b) protecting podocyte via restoring in SD rats; (c) regulating hypertrophy and migratory capacity of glomerular mesangial cell; (d) participating in glomerulosclerosis ...

Mar 7, 2024 · Cell division cycle 42 (CDC42) regulates podocyte apoptosis to take part in the development and progression of diabetic nephropathy (DN), but currently the clinical evidence is limited.

Jan 6, 2019 · Cdc42, a member of the Rho GTPases family, is involved in the regulation of several cellular functions including cell cycle progression, survival, transcription, actin cytoskeleton organization and membrane trafficking.

Cdc42 is a highly conserved small GTP-binding protein that is involved in regulating morphogenesis in eukaryotes. In this study, we isolated and characterized a highly conserved Cdc42 gene from Colletotrichum trifolii (Ct Cdc42), a fungal pathogen of alfalfa.

CDC42 may retard DN progression via its regulation of renal tubular epithelial cell functions, which may be due to its stimulation of the PAK1/AKT pathway.

Nov 13, 2024 · Our two previous studies observed that cell division cycle 42 (CDC42) was lower and correlated with improved renal function and inflammation in diabetic nephropathy (DN) patients, and CDC42 inhibited renal tubular epithelial cell fibrosis and inflammation under high glucose condition.

Jan 4, 2000 · CDC42, a Ras-related small GTP binding protein, is involved in diverse cellular functions in lymphocytes. We generated transgenic mice expressing constitutively active murine CDC42 (Q61L) under...

May 4, 2016 · We identify N-WASP as a novel interaction partner of CRN7 and demonstrate that CRN7 restricts spurious F-actin reorganizations by repressing N-WASP ‘hyperactivity’ upon constitutive Cdc42...

Mar 23, 2018 · To examine the role of Cdc42 signaling in cerebellar GCP development, we first over-expressed Venus fluorophore-tagged dominant negative (DN) Cdc42 (Venus-Cdc42N17) to block Cdc42 activity and Venus fluorophore-tagged …

Jan 6, 2019 · Cdc42 regulates the pathogenesis of DN by (a) promoting podocyte injury through interacting with some receptors and enzymes (such as TGF-β, SRGAP2a, PI3K, PTEN, and NMDARs); (b) protecting podocyte via restoring in SD rats; (c) regulating hypertrophy and migratory capacity of glomerular mesangial cell; (d) participating in glomerulosclerosis ...