CCR6 is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation.

Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. [5] CCR6 has also recently been designated CD196 (cluster of differentiation 196). The gene is located on the long arm of Chromosome 6 …

Early DC recruitment depends in part on CCR2 to traverse vascular endothelium, plus CCR6 to traverse alveolar epithelium. The recruitment of circulating immature DC represents a potential therapeutic step at which to modulate immunological lung diseases.

Here, we demonstrate that a specialized DC subset in Peyer's patches (PPs) mediates the rapid activation of pathogen specific T cells. This DC subset is characterized by the expression of the chemokine receptor CCR6 and is found only in PPs.

In this article, we provide data that link CCR6-mediated DC influx into the lung as a necessary component of host defense in neutropenic mice with invasive aspergillosis. Several studies have examined the role of DCs in the immune response to Aspergillus species.

CCR6 is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation.

These three cell types have specialized func-tion; the myeloid type (CD11b+CD8a2CCR6+) activates primarily T helper (Th)-2 T cells that produce IL-10, the CD11b2CD8a+CCR62 DCs are localized in the T cell in-terfollicular area (IFR) and activate Th1-type responses, and the CD11b2CD8a2CCR6+ DCs are located both in the SED and in the IFR and can al...

CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3alpha (MIP-3alpha) or Exodus-1, is the only chemokine known to interact with CC chemokine receptor 6 (CCR6), a property shared with the antimicrobial beta-defensins.

Recruitment of circulat-ing DC precursors, including Gr1+monocytes, pre-cedes the sequential accumulation of CD11c+ MHC class II+DCs in dermis and epithelium via a CCR6/ CCL20-dependent mechanism.

Apr 1, 2005 · In this study we show that the chemokine receptor CCR6 is expressed on a distinct subset of mouse Treg cells. Similar to their CD25 - counterparts, CCR6 + Treg cells exhibit markers of activation, memory, and expansion that are indicative for an effector-memory function.