CCL5 belongs to the CC subfamily of chemokines, due to its adjacent cysteines near N terminus. It is an 8kDa protein acting as a classical chemotactic cytokine or chemokine. It consists of 68 amino acids. CCL5 is proinflammatory chemokine, recruiting leukocytes to …

Mar 30, 2025 · CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

CCL5/CCR5 axis promotes VEGF production by attracting endothelial progenitor cells (EPCs). The CCL5-overexpressing-osteosarcoma makes EPCs migrate to abnormal sites.

Introduction: Chemokines play important roles in inflammation and in immune responses. This article will discuss the current literature on the C–C chemokine ligand 5 (CCL5), and whether it is a therapeutic target in the context of various allergic, autoimmune or infectious diseases.

Sep 27, 2024 · Our findings demonstrate the significant potential of CCL5 as an immunotherapeutic response biomarker and prognostic indicator, which may pave the way for more studies on the mechanism of tumor...

CCL5 (also RANTES) is a chemokine that provides activating and chemotactic signalling to T lymphocytes, basophils and eosinophils of the peripheral immune system (Murphy et al., 2000). In the CNS, CCL5 is constitutively expressed by microglia …

Apr 30, 2021 · CCL5 promotes aerobic glucose metabolism, mitochondrial ATP generation and purine synthesis, improving synaptic plasticity and enhancing memory and cognition functions.

CCL5's Role in Periodontal Disease: A Narrative Review. Low peripheral blood chemokine (C-C motif) ligand 5 and tumor necrosis factor alpha gene expression is associated with unfavorable progression of respiratory syncytial virus bronchiolitis in infants.

4 days ago · CCL5 was added at the desired concentrations, while hCCL5 and Met-hCCL5-K25S were used as the positive and negative controls, respectively 33. The protein concentration was 20 ng/ml. All ...

Feb 8, 2025 · It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]