CCL2 - Wikipedia
The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the …
More Than Just Attractive: How CCL2 Influences Myeloid Cell …
Emerging evidence shows that it can impact leukocyte behavior, influencing adhesion, polarization, effector molecule secretion, autophagy, killing, and survival. The direction of …
Bad Cancer ISGs in Immunotherapy — Andy Minn Lab at UPenn
Increase in NFkB inflammatory cytokines such as CCL2 and CXCL1 that support the development of suppressive myeloid cells. This can create an immunosuppressive tumor microenvironment …
Regulation of macrophage IFNγ-stimulated gene expression by …
Jan 1, 2023 · Here, we show that the closely related Cited1 is an ISG, which is expressed in a STAT1-dependent manner, and that IFNγ stimulates the nuclear accumulation of CITED1 …
CCL2 in the Tumor Microenvironment - PubMed
CCL2 plays a role in recruiting tumor-associated macrophages (TAMs), which adopt a pro-tumorigenic phenotype and support cancer cell survival, facilitate tumor cell invasion, and …
CC Chemokine Ligand-2: A Promising Target for Overcoming …
CC chemokine ligand-2 (CCL2), a proinflammatory chemokine that mediates chemotaxis of multiple immune cells, plays a crucial role in the tumor microenvironment (TME) and promotes …
IFI35 limits antitumor immunity in triple-negative breast cancer via ...
Jan 12, 2024 · Mechanistically, RNA-sequencing reveals that IFI35 promotes CCL2 secretion, resulting in the remodeling of TNBC immune microenvironment. Ablation of IFI35 promotes the …
Frontiers | CCL2: An important cytokine in normal and pathological ...
Jan 6, 2023 · In this review, we concentrate on CCL2 expression at the maternal-fetal interface, as well as its precise regulatory mechanisms and classic signaling pathways, to reveal the …
IκBζ Is a Transcriptional Key Regulator of CCL2/MCP-1
May 1, 2013 · To investigate whether expression of Ccl2 and CCL2 secretion were generally impaired in IκBζ-deficient cells, we analyzed the kinetics of Nfkbiz and Ccl2 induction in IFN …
Insights into CC Chemokine Ligand 2/Chemokine Receptor 2 …
Jun 1, 2017 · Chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein 1 (MCP-1), is a chemokine that recruits immune cells to inflammatory sites by interacting with G …