Effects of BMZ on adrenocortical mRNA levels for P450scc (A), StAR (B) and ACTH Receptor (C) in maternal (left) and pooled fetal (right) adrenals. Results are from n= 6-7 replicates in each group of rabbits.

Our primary goal was to determine if the IVH lowering effects of BMZ might be time-limited, because this would increase the risk that a severe IVH might occur if an infant delivered more than a week (≥10 days) after BMZ treatment and still within the …

Apr 7, 2016 · We designed a randomized trial to assess whether the administration of betamethasone to women who are likely to deliver in the late preterm period would decrease respiratory and other neonatal...

Study infants were divided into 2 groups depending on the interval from the first dose of BMZ to delivery (BMZ-to-delivery-interval), namely group A (24 hours to 9 days) with n=290 neonates and group B (≥10 days, eligible for rescue or retreatment) with n=120 neonates .

Betamethasone and dexamethasone are the most widely studied corticosteroids, and they generally have been preferred for antenatal treatment to accelerate fetal organ maturation. Both cross the placenta in their active form and have nearly identical biologic activity.

Purpose: Administration of maternal betamethasone (BMZ) is a therapeutic option for fetuses with large microcystic congenital lung lesions at risk for, or causing, hydrops. Not all fetuses respond to a single course of BMZ.

Objective: To evaluate the effects of a single rescue dose of antenatal betamethasone after an initial single course on the frequency of neonatal respiratory distress syndrome and perinatal infectious morbidity in pregnancies complicated with preterm labor and delivery.

Our analysis supports the concept that the optimal timing of benefit for BMZ is greater than 48 hours of administration. Although the standard regimen for late preterm birth (LPTB) antenatal corticosteroids involves two doses of betamethasone given 24 hours apart, not all women remain pregnant long enough to receive a second dose.

Objective: Review the latency period after betamethasone (BMZ) for pregnancies complicated by hypertensive disorders of pregnancy (HDP). Study design: A retrospective chart review of patients that received BMZ for the reduction of preterm morbidity for HDP.

Study design: A total of 429 infants (<28 weeks gestation), who delivered ≥24 hours after the first betamethasone (BMZ) course (2 doses), were divided into groups based on the interval between the first course of BMZ and delivery: <10 days or ≥10 …