B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family of proteins, and acts as an anti-apoptotic protein by preventing the release of mitochondrial contents such as cytochrome c, which leads to caspase activation and ultimately, programmed cell ...

May 18, 2020 · Cell Death & Disease - BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells

Bcl-X L is essential for the survival of neurons and plays protective roles in neuronal injuries. It can promote the growth of neurons and the correct formation of neural networks, enhance synaptic plasticity, and control neurotoxicity.

Jan 6, 2020 · Here we characterize the role of BCL-XL for survival and function of human hematopoietic cells, with the aim to predict hematological side effects of novel BCL-XL-inhibiting BH3-mimetics and...

Jan 1, 2020 · Bcl-X L is one of the key regulators of apoptosis that can also regulate other important cellular functions. Bcl-X L is overexpressed in many cancers, and its inhibitors have shown good therapeutic effects. Bcl-X L interacts with Beclin 1, a key factor regulating autophagy.

Feb 4, 2025 · Here, we investigated BCL2 and BCL-XL, the genes that encode BCL2 and BCL-XL, and their expression differences between B-cell acute lymphoblastic leukemia (B-ALL) and T-cell ALL (T-ALL). We also evaluated the therapeutic potential of targeting these proteins with AZD0466, a novel drug-dendrimer conjugate of the BCL2/BCL-XL inhibitor AZD4320 ...

The bh4 domain of anti-apoptotic bcl-xl, but not that of the related bcl-2, limits the voltage-dependent anion channel 1 (vdac1)-mediated transfer of pro-apoptotic ca2+ signals to mitochondria. J. Biol.

Oct 17, 2020 · By RNA sequencing analysis of a pan-cancer cohort comprising >1500 patients and subsequent prediction of protein activity, BCL-XL was identified as the only antiapoptotic BCL-2 protein that is...

2 days ago · Bcl-xL overexpression partially rescued the hypersensitivity to DNA damage of Gfi1-knocked down leukemic cells and Gfi1-deficient mouse primary bone marrow (BM) cells. In contrast, Bcl-xL knockdown partially abolished the protective effect of Gfi1 on DNA damage-induced apoptosis. Notably, interaction with LSD1 was required and sufficient for ...

Bcl-xL is a major inhibitor of apoptosis, a fundamental homeostatic process of programmed cell death that is highly conserved across evolution. Because it plays prominent roles in cancer, Bcl-xL is a major target for anticancer therapy and for ...