Some of the more heavily studied proteins of importance for the control of growth arrest and apoptosis are p53, p21, bcl-2 and bax. Alterations in the p53 protein may lead to malignant transformation and defect therapy response, most likely as a …

Mar 31, 2022 · In the current synopsis, the mechanism of regulation by p53-p21-RB signaling is assessed and the overlap with p53-p21-DREAM signaling is examined. The tumor suppressor p53 can induce cell...

May 31, 2017 · Here, we report that although p53 can bind Bcl-w alone, it requires p21 to liberate Bax to suppress cell invasion and promote cell death. p21 bound Bcl-w, forming a p53/p21/Bcl-w complex in a manner that maintained all pairwise p53/p21, p21/Bcl-w, and p53/Bcl-w interactions.

These results suggest that, following SSR, normal human skin induces apoptosis by the p53, p21waf1/Cip1, Bax pathway in vivo. In addition, induction of apoptosis and expression of p53, p21waf1/Cip1 and Bax occurs in a dose-dependent manner.

Our study was designed to determine the effect of UV on the expression of p53, p21 waf1/cip,1, and Bax and the induction of apoptosis in vivo in previously non-sun exposed buttock skin in normal controls and patients with BCC to identify a possible inherent susceptibility to BCC.

Results: TUNEL-positive cells showed a positive correlation with bax (P = 0.010) and a negative correlation with p21 (P = 0.04). We also investigated the relationship between p53 point mutation, p21 immunostaining degree, and apoptosis, based on DNA ladder expression.

In this study, we continue our efforts in elucidating the mechanism of actions of 5OH-PMFs in inhibiting colon cancer cell growth. Using isogenic variants of human colon cancer cells HCT116, we investigated the effects of p53, Bax and p21 status on the apoptosis and cell cycle arrest induced by three major 5OH-PMFs.

Jan 20, 2021 · In general, REs at cell cycle arrest targets (e.g. p21) are of higher affinity than those at apoptosis targets (e.g., BAX). However, the RE sequence code underlying selectivity remains...

In this study, we examined the gene expression levels in the cerebellum after whole body exposure of BALB/c mice to a mobile phone. Four genes (bax, bcl-2, p21 and p53) were quantified in independent samples from the four groups (control, B1, B2, and B3) by …

Mar 22, 2025 · Monitoring apoptosis in breast cancer cells is crucial for understanding the molecular mechanisms underlying breast cancer and evaluating the therapeutic effects of anticancer drugs. Real-time monitoring of p21 mRNA and Bax mRNA during apoptosis offers a valuable tool for assessing drug efficacy.