Jul 2, 2024 · Here we show that BRD7, a component of the polybromo-associated BAF complex (PBAF), was required for naive CD8+ T cells to differentiate into functional short-lived effector cells (SLECs) in response to acute infections caused by influenza virus or lymphocytic choriomeningitis virus (LCMV).

Jul 2, 2024 · Here we show that BRD7, a component of the polybromo-associated BAF complex (PBAF), was required for naive CD8 + T cells to differentiate into functional short-lived effector cells (SLECs) in response to acute infections caused by influenza virus or lymphocytic choriomeningitis virus (LCMV).

Here, we discuss recent advancements in understanding the relationship between the pBAF complex and developmental processes, primarily focusing on the function of each pBAF-specific subunit: ARID2, PBRM1, PHF10, and BRD7.

Nov 21, 2008 · Using short hairpin RNA-mediated depletion of BRG1, we showed that SWI/SNF can function as both a repressor and an activator in pluripotent cells, regulating expression of developmental modifiers and signaling components such as Nodal, ADAMTS1, BMI-1, CRABP1, and thyroid releasing hormone.

Dec 10, 2022 · Here we determined structure of 13-subunit human PBAF in complex with acetylated nucleosome in ADP-BeF 3 -bound state. Four PBAF-specific subunits work together with nine BAF/PBAF-shared...

Aug 8, 2010 · BRD7 is a deletion target in human cancer, suggesting that loss of BRD7 may provide an additional mechanism to antagonize p53 function in cancer cells. Keywords: cancer, PBAF, SWI/SNF, p21. Replicative senescence is a permanent cell-cycle arrest induced by telomere attrition in aged cells.

Nov 21, 2008 · Among our main observations is the identification of BRD7 as a new PBAF-specific subunit. We found BRD7 present in purifications from pluripotent ESCs, differentiated ESCs, and HeLa cells, arguing for its incorporation in a variety of cell types.

BRD7 (bromodomain 7), a novel bromodomain-containing protein of about 75 kD (BRD7), also known as celtix-1, is a subunit of polybromo-associated BRG1-associated factor (PBAF)- specific Swi/Snfchromatin remodeling complexes .

Here we show that BRD7, a component of the polybromo-associated BAF complex (PBAF), was required for naive CD8+T cells to differentiate into functional short-lived effector cells (SLECs) in response to acute infections caused by influenza virus …

Jul 2, 2024 · Our research confirms BRD7 and the PBAF complex are key in CD8 + T. cell development and present a significant target for advancing immune therapies. including viruses. In response to viral...