The antitumorigenic roles of BRCA1–BARD1 in DNA repair and
Feb 24, 2020 · In this Review, we discuss recent advances in elucidating the mechanisms by which BRCA1–BARD1 functions in DNA repair, replication fork maintenance and tumour …
The BRCA1/BARD1 ubiquitin ligase and its substrates - PMC
In this review, we discuss the Ub ligase function of BRCA1/BARD1, highlighting experimental approaches, mechanistic considerations, and reagents that are useful in the study of substrate …
Mechanism of BRCA1–BARD1 function in DNA end resection and …
Sep 11, 2024 · Using purified recombinant proteins, we show here that BRCA1–BARD1 directly promotes long-range DNA end resection pathways catalysed by the EXO1 or DNA2 …
BARD1 mystery: tumor suppressors are cancer susceptibility genes
Jun 22, 2022 · BARD1, as a BRCA1 heterodimer interactor that plays an essential role as a tumor suppressor gene altered in breast and ovarian cancers, was also found to display a BRCA1 …
The BRCA1/BARD1 ubiquitin ligase and its substrates - PubMed
Sep 30, 2021 · In this review, we discuss the Ub ligase function of BRCA1/BARD1, highlighting experimental approaches, mechanistic considerations, and reagents that are useful in the …
Crucial Roles of the BRCA1-BARD1 E3 Ubiquitin Ligase Activity in ...
Using full-length BRCA1-BARD1, we establish robust BRCA1-BARD1-mediated ubiquitylation with specificity, uncover multiple modes of activity modulation, and construct a truly ligase-null …
Mechanisms of BRCA1–BARD1 nucleosome recognition and
Jul 28, 2021 · Our work reveals a regulatory crosstalk in which recognition of monoubiquitin by BRCA1–BARD1 at the N terminus of H2A blocks the formation of polyubiquitin chains and …
Structural insight into BRCA1-BARD1 complex recruitment to …
Jul 1, 2021 · The BRCA1-BARD1 complex directs the DNA double-strand break (DSB) repair pathway choice to error-free homologous recombination (HR) during the S-G2 stages. …
Structural insight into BRCA1-BARD1 complex recruitment to …
Jul 1, 2021 · BRCA1-associated RING domain protein 1 (BARD1) is an obligate binding partner of BRCA1 in cells, and it forms a stable complex with BRCA1 via their N-terminal RING domains …
BARD1 BRCA1 associated RING domain 1 [ Homo sapiens (human) ]
Mar 16, 2025 · Title: BRCA1-BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes. Exome sequencing identifies breast cancer susceptibility genes and …