This test uses fluorescence in situ hybridization (FISH) to detect molecular rearrangement of the BCR and ABL1 genes involved in translocation t (9;22).

Mar 31, 2025 · For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to …

Aids in exclusion of cryptic BCR-ABL1 rearrangement in chronic myelogenous leukemia and in the exclusion of a PDGFRA abnormality in cases of neoplastic eosinophilia.

In CML, FISH can be used to look for specific pieces of the BCR-ABL gene on chromosomes. It can be used on regular blood or bone marrow samples without growing the cells first, so you get the results more quickly than with conventional cytogenetics.

Conclusions: We confirm that QRT-PCR allows precise measurement of low levels of BCR-ABL transcripts and can serve as a sensitive indicator for minimal residual disease. In addition, we demonstrate in most cases a good correlation of QRT-PCR with FISH in detecting the BCR-ABL fusion gene among patients with CML or Ph+ ALL.

Interphase fluorescence in situ hybridization (I-FISH) for the BCR-ABL translocation performed on peripheral blood (PB) white cells has been suggested as a surrogate for conventional bone marrow (BM) cytogenetics for monitoring patients with chronic myeloid leukemia (CML).

Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as a BCR-ABL-1-like ALL, is a high-risk subset with a gene expression profile that shares significant overlap with that of Ph-positive (Ph+) ALL and is suggestive of active kinase signaling.

Apr 3, 2025 · BCR-ABL for chronic myelogenous leukemia (CML), FISH; chromosome analysis; quantitative monitoring for CML by FISH; ABL deletions are confirmed by linked ASS analysis.

Explore the Bcr-Abl fusion's role in chronic myeloid leukemia (CML) detection through Fish technique. Discover methodologies, challenges, and future research. 🔬📊

The Vysis BCR/ABL1/ASS1 Tri-Color DF FISH Probe Kit is intended to detect the t (9;22) (q34;q11.2) reciprocal translocation involving the BCR and ABL1 gene regions using the fluorescence in situ hybridization (FISH) technique.